December 2025 in “The Journal of Cell Biology” This study found that keratin 15 lacks the ability to sequester YAP1 in keratinocytes effectively, unlike keratin 14, and suggests that a higher K15:K14 ratio may promote a progenitor state and inhibit differentiation in epidermal keratinocytes.
February 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” This study proposes a model suggesting that the ratio of keratin 15 to keratin 14 in epidermal keratinocytes promotes a progenitor state and opposes differentiation, based on insights from both cell culture and transgenic mouse models.
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August 1998 in “The Journal of Cell Biology” In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.
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July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that centrosome ablation in developing epidermis triggers cell surveillance pathways, resulting in thinner skin and halted hair follicle growth, while later stages of epidermal growth may operate independently of basal progenitor division orientation.
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September 2015 in “Elsevier eBooks” This review discusses the role of Sox2 in skin development, hair follicle regeneration, cancer, and wound healing, and reports no new experimental results.