Safety Evaluation of Topical Valproate Application

June 2013 in “ Toxicological Research ”

Sun Young Choi, Song Yi Seop, Moo Yeol Hyun, Kwang Ho Yoo, Beom Joon Kim, Myeung Nam Kim, Jae-We Cho

topical Valproate VPA hair regrowth HaCaT keratinocytes fibroblasts RBL-3H mast cells microneedle rollers transdermal drug delivery erythema Valproate skin cells transdermal delivery skin redness

TLDR Topical Valproate is safe for human skin and unlikely to cause irritation.

In 2013, a safety evaluation was conducted on topical Valproate (VPA), a mood stabilizer suggested to stimulate hair regrowth, involving 20 healthy volunteers aged 21 to 43 years. Cell viability tests on HaCaT keratinocytes, fibroblasts, and RBL-3H mast cells showed no toxicity from VPA. A clinical patch test and a skin irritation test using microneedle rollers for transdermal drug delivery were also performed, with only one patient showing minimal erythema at 1 hour, which disappeared within a few hours. No significant findings were obtained in the clinical patch test. The study concluded that VPA has minimal potential to cause skin irritation and can be safely applied to human skin.

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research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

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research Safety Evaluation of Topical Valproate Application

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Topical Valproate is safe for human skin and unlikely to cause irritation.