Effect of Adenosine Triphosphate on Ribociclib-Induced Skin Toxicity in Rats

January 2023 in “ Cutaneous and Ocular Toxicology ”

Nurcan Akbaş, Enver Akbaş, Zeynep Süleyman, Betül Çiçek, Ahmet Gökhan Ağgül, Behzad Mokhtare, Halis Suleyman

adenosine triphosphate ribociclib CDK4/6 inhibitor dermal necrosis hair follicle degeneration malondialdehyde antioxidant enzymes superoxide dismutase catalase total glutathione ATP MDA SOD CAT tGSH

Studysummary This study found that ATP may help reduce ribociclib-induced skin damage in rats by mitigating biochemical changes associated with oxidative stress. Our plain-language summary of this paper — not a Tressless recommendation.

This study investigated the effects of adenosine triphosphate (ATP) on skin damage induced by ribociclib, a CDK4/6 inhibitor used in breast cancer treatment, using a rat model. The study involved 18 rats divided into three groups: ATP + Ribociclib (ATR), Ribociclib (RCB), and a healthy control (HC). Over 15 days, the RCB group exhibited significant skin damage, including dermal necrosis and hair follicle degeneration, along with increased malondialdehyde (MDA) levels and decreased antioxidant enzyme levels (SOD, CAT, tGSH). In contrast, the ATR group showed only mild degeneration, with ATP administration reducing MDA levels and mitigating the decrease in antioxidant enzymes. The findings suggested that ATP could potentially be beneficial in treating ribociclib-induced skin toxicity.

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research Effects of Adenosine Triphosphate on Vandetanib-Induced Skin Damage in Rats

3 citations , August 2020 in “Cutaneous and Ocular Toxicology”

This study demonstrated that adenosine triphosphate may prevent vandetanib-induced skin toxicity in rats, suggesting potential for further research in other animal models and humans.