Cutaneous Toxicity as a Predictive Biomarker for Clinical Outcome in Patients Receiving Anticancer Therapy

May 2018 in “ Journal of the American Academy of Dermatology ”

Alexandra K. Rzepecki, Haiying Cheng, Beth N. McLellan

cutaneous toxicity skin toxicities molecularly targeted kinase inhibitors immune checkpoint inhibitors cytotoxic chemotherapeutics dermatologic events

TLDR Skin reactions from cancer treatments might predict how well the treatments work.

The article discussed the potential of cutaneous toxicity as a predictive biomarker for clinical outcomes in patients undergoing anticancer therapy. It reviewed the association between skin toxicities caused by molecularly targeted kinase inhibitors, immune checkpoint inhibitors, and cytotoxic chemotherapeutics, and the survival benefits observed in patients. Preliminary studies suggested a promising link, but larger prospective studies were needed to confirm this relationship. The article emphasized the importance of dermatologists collaborating with oncologists to manage these dermatologic events, which could help in recognizing the efficacy of anticancer treatments and influence treatment decisions and patient outcomes.

View this study on jaad.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 12 results

community How do you use rosemary oil and peppermint oil?

in Question 6 upvotes 4 years ago

Rosemary oil and peppermint oil may promote hair growth and increase cutaneous blood flow, showing promise as treatments for androgenetic alopecia. Minoxidil 2% is also used for treating hair loss.

community Scientific evidence for Peppermint & Rosemary oils + My Experience

in Research/Science 114 upvotes 1 year ago

Natural treatments for hair loss, specifically peppermint oil and rosemary oil; how they can be used as a supplementary or alternative treatment to pharmaceuticals such as finasteride and minoxidil; and the personal experience of the user Divallo, who has seen an increase in density and thickness after using these oils for around 2.5 years. The post also touches on the potential antifungal properties of the oils and their effects on cutaneous blood flow.

community high bloodpressure and crown thinning in early 20s

in Is this regrowth? 9 upvotes 5 months ago

A user with kidney disease and high blood pressure experienced hair thinning, especially around the vertex. They are currently using finasteride and oral minoxidil but are considering whether to resume blood pressure medication despite managing symptoms with diet and exercise.

community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

in Research/Science 108 upvotes 1 year ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Why is everyone not directly advised Dutasteride?

in Finasteride/Dutasteride 165 upvotes 1 month ago

Dutasteride is less commonly prescribed for hair loss because it is not FDA-approved for this purpose, unlike finasteride, which is more accessible and preferred due to fewer side effects. Dutasteride may be more effective in reducing DHT but has a longer half-life and potentially more significant side effects.

Similar Research

5 / 1000+ results

research Dermatologic Adverse Events from Cancer Treatments

2 citations, October 2018 in “Springer eBooks”

Cancer treatments can cause skin-related side effects that may affect patient quality of life and require changes in treatment.

research Cancer-Related Alopecia: From Etiologies to Global Management

4 citations, November 2021 in “Cancers”

The document concludes that understanding and managing hair loss in cancer patients is important, and more research is needed for better treatments.

research Prophylaxis and Management of Skin Toxicities

15 citations, January 2019 in “Breast care”

Preventive measures and effective management are crucial for reducing skin side effects in cancer treatment.

research Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails

179 citations, October 2018 in “American Journal of Clinical Dermatology”

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

research Adverse Hair Reactions to New Targeted Therapies for Cancer

1 citations, March 2019 in “Actas Dermo-Sifiliográficas”

New cancer treatments are less harmful to hair but can still cause hair loss, color, shape, and growth changes.