Cutaneous Lesions in Rats Following Administration of an Irreversible Inhibitor of ErbB Receptors, Including the Epidermal Growth Factor Receptor
April 2008
in “
Toxicologic Pathology
”
Studysummary This study found that CI-1033 caused skin lesions in rats that resemble effects seen in humans receiving EGF receptor inhibitors, suggesting this animal model can help explore the mechanisms behind this cutaneous toxicity.
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