Natural Products Reverse Cancer Multidrug Resistance
March 2024
in “
Frontiers in Pharmacology
”
Studysummary This review highlights the potential of natural product-derived compounds, such as flavonoids and alkaloids, to reverse multidrug resistance in tumors, emphasizing their role in regulating signaling pathways, proteins, and genes related to MDR, and aims to guide future research efforts in this area.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Multidrug resistance (MDR) is a major obstacle in effective cancer chemotherapy, but recent research highlights the potential of natural product-derived compounds to reverse this resistance. Compounds such as flavonoids, alkaloids, terpenoids, polyphenols, and coumarins have shown promise in modulating MDR by influencing signaling pathways and gene or protein expression. This review consolidates past achievements and recent advancements in using natural products to combat MDR, offering insights into their potential as treatments to overcome chemotherapy resistance in tumors.
