Medications Mostly Associated With Ejaculatory Disorders: Assessment of the EudraVigilance and Food and Drug Administration Pharmacovigilance Databases Entries

    February 2024 in “ Urology ”
    Antonio Nacchia, Antonio Franco, Antonio Cicione, Sara Riolo, Giuseppe Santoro, Matteo Romagnoli, Luca Sarcinelli, Daniele Fiasconaro, Nicola Ghezzo, Giacomo Gallo, Giorgia Tema, Antonio Luigi Pastore, Yazan Al Salhi, Andrea Fuschi, Antonino Carbone, Giorgio Franco, Riccardo Lombardo, Andrea Tubaro, Cosimo De Nunzio
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    TLDR Certain medications, especially Paroxetine, Tamsulosin, and Finasteride, are linked to ejaculatory disorders.
    The study aimed to identify medications most associated with ejaculatory disorders using data from the FDA-FAERS and Eudra-Vigilance databases. From 7,404 reports, 92.6% were linked to ten specific medications. Paroxetine and Tamsulosin were primarily responsible for delayed and retrograde ejaculation, respectively. Finasteride was notably associated with painful ejaculation and ejaculation failure. Sildenafil showed a higher risk of ejaculatory disorders compared to Tadalafil. The findings suggest that physicians should inform patients about these risks, and further clinical trials are recommended to validate these results.
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