TLDR CD80CD86 deficiency causes hair loss by disrupting regulatory T cells.
The study investigated autoimmune-like alopecia (ALA) in CD80CD86-deficient (B6.CD80CD86−/−) mice, revealing that nearly 100% of these mice experienced hair loss by 40 weeks of age. The deficiency led to a significant reduction in CD4+FoxP3+ regulatory T cells (Tregs), which is believed to trigger autoimmune reactions. Histological analysis showed CD4+ and CD8+ T-cell infiltration and hair follicle destruction. The study confirmed a negative correlation between Treg numbers and ALA severity. The findings suggested that B6.CD80CD86−/− mice could serve as a valuable model for studying ALA due to their high disease incidence and similarities to human alopecia areata.
Cited in this study
4 / 4 results
82 citations
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July 2017 in “Experimental dermatology” CD80CD86 deficiency causes hair loss by disrupting regulatory T cells.
185 citations
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January 2006 in “Autoimmunity Reviews” Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.
