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CD80CD86 Deficiency Disrupts Regulatory CD4+FoxP3+ T Cell Homeostasis and Induces Autoimmune-Like Alopecia

research CD80CD86 deficiency disrupts regulatory CD4+FoxP3+T cell homoeostasis and induces autoimmune-like alopecia

6 citations , April 2017 in “Experimental dermatology”

This study found that B6.CD80CD86−/− mice developed autoimmune-like alopecia with nearly 100% incidence by 40 weeks, making them a promising model for studying human alopecia areata.

Topical Mechlorethamine Restores Autoimmune-Arrested Follicular Activity in Mice with an Alopecia Areata-Like Disease by Targeting Infiltrated Lymphocytes

research Topical Mechlorethamine Restores Autoimmune-Arrested Follicular Activity in Mice with an Alopecia Areata-Like Disease by Targeting Infiltrated Lymphocytes

19 citations , March 2003 in “Journal of Investigative Dermatology”

This study found that mechlorethamine restored hair growth in mice with alopecia-areata-like disease by eliminating infiltrated lymphocytes and inhibiting certain pro-inflammatory cytokines in treated skin areas.

Imipramine-Induced Alopecia Areata-Like Lesions

research Imipramine-lnduced Alopecia Areata-like Lesions

7 citations , April 1987 in “International Journal of Dermatology”

This article reports no new clinical findings and provides no abstract, focusing on imipramine-induced lesions resembling alopecia areata.

Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy–Like Autoimmune Disease

research Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy–like Autoimmune Disease

26 citations , June 2018 in “The journal of immunology/The Journal of immunology”

This study demonstrated that AIRE-deficient rats exhibit key symptoms of APECED, making them a relevant model for exploring potential treatments.

research LB789 Novel IFNγ aptamer TAGX-0003 protected hair follicles from immune privilege collapse and reversed Alopecia Areata like phenotype in humanized mouse model

August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

This article reviews current treatments for alopecia areata, discussing the potential role of JAK inhibitors and noting the need for further clinical trials, but it reports no new results.

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Community Join

5 / 204 results

community My 15+ Year Hair Loss Journey: DUPA, Recurrent Alopecia Areata, & different dosages of Min / Fin topicals - Advice needed on next steps.

4 upvotes 2 weeks ago

The user has been managing hair loss for over 15 years, using treatments like Minoxidil, Finasteride, and corticosteroids, while experiencing side effects and recurrent Alopecia Areata. They seek advice on progression and potential underlying conditions, questioning if their hair loss is due to an autoimmune issue beyond typical patterns.

community Arthritis drug restores 100% hair on 1 in 5 alopecia patients in global trial

150 upvotes 2 weeks ago

An arthritis drug, Rinvoq, restores hair in some alopecia areata patients but is not effective for androgenetic alopecia. It is used for autoimmune-related skin disorders, but its high cost and lack of insurance coverage are issues.

community 6 months on dutast and minoxodil, hair growing like weeds now!

in Progress Pictures 618 upvotes 1 year ago

A woman experienced significant hair regrowth after six months of using dutasteride and minoxidil, despite initial hair loss due to androgenetic alopecia. She reported minimal side effects and highlighted the effectiveness of these treatments for women, despite doctors' hesitancy to prescribe them.

community Why Fin/Dut is always recommended. The top 10 reasons for hairloss in men.

2 upvotes 1 year ago

Hair loss in men is primarily caused by androgenetic alopecia, with treatments like finasteride and dutasteride often recommended. Other causes include stress, nutritional deficiencies, medications, and scalp infections.

community Losing Hair on Dutasteride? You might have LPP

96 upvotes 1 year ago

Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

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Learn

7 / 10 results

learn Baicapil

Struggling with patchy hair loss like alopecia areata? Baicapil might help by reducing inflammation and reactivating growth. There is no published trial of Baicapil in alopecia areata. The anti-inflammatory and hair-density claims come from the ingredient's manufacturer and from laboratory work on its plant extracts, in people with androgenetic-type hair loss rather than autoimmune patchy hair loss.