Mast Cell Hyperplasia in the Skin of Dsg4-Deficient Hypotrichosis Mice, Long-Living Mutants of Lupus-Prone Mice

August 2008 in “ Immunogenetics ”

Ming Cai Zhang, Hiroshi Furukawa, Kazuhiro Tokunaka, Kan Saiga, Fumiko Date, Yuji Owada, Masato Nose, Masao Ono

mast cell hyperplasia desmoglein 4 Dsg4 hypotrichosis hair follicle anagen mast cell precursors mast cells hair loss hair growth phase

TLDR A gene mutation in mice causes increased mast cells and disorganized hair follicles in their skin.

The study found that a mutation in the desmoglein 4 (Dsg4) gene in mice with hypotrichosis led to mast cell hyperplasia in their skin. This mutation was due to the insertion of an early transposon II-β into intron 8 of Dsg4. The EODhage mice, long-living mutants from lupus-prone EOD mice, exhibited a reduction in the expanded population of lpr T cells. The research suggested that Dsg4 was essential for hair follicle formation, and the mutation caused disorganized hyperplastic hair follicles in anagen, creating niches for mast cell precursors in the skin.

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Research cited in this study

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research Desmoglein 4 Mutations Underlie Localized Autosomal Recessive Hypotrichosis in Humans, Mice, and Rats

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