Histopathology of Hypotrichosis with Juvenile Macular Dystrophy

May 2004 in “ The American Journal of Dermatopathology ”

Reuven Bergman, Marcela Sapir, Eli Sprecher

Hypotrichosis with Juvenile Macular Dystrophy HJMD CDH3 gene R503H mutation hair follicles catagen-telogen hair follicles vellus hair terminal hair P-cadherin anagen phase catagen phase telogen phase sparse hair short hair hair thinning

TLDR The research found that a specific gene mutation causes fewer hair follicles and disrupted hair growth cycles, leading to thin and short hair in people with Hypotrichosis with Juvenile Macular Dystrophy.

The study investigated the histopathology of Hypotrichosis with Juvenile Macular Dystrophy (HJMD), a condition caused by CDH3 gene mutations and characterized by sparse hair and progressive vision loss. Scalp biopsies from 6 patients with a specific homozygous mutation (R503H) in the CDH3 gene showed a low number of hair follicles, ranging from 6 to 14 per section, without inflammation or scarring. There was a notable increase in catagen-telogen hair follicles in five patients and a higher vellus to terminal hair follicle ratio in two patients. The findings suggested that the lack of functional P-cadherin disrupts the hair cycle, leading to shorter anagen phases and prolonged catagen and telogen phases, causing the hair thinning and short hair observed in HJMD.

View this study on journals.lww.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 100 results

community Fin/min/microneedling ~9 months – no results, actually worse

in Progress Pictures 96 upvotes 1 year ago

User harlital shared their 9-month hair loss journey using finasteride, minoxidil, and microneedling but experienced worse results. Commenters suggested patience, checking for other causes, and considering dutasteride after 12-24 months if no improvement.

community 15 Week Update of Oral Consumption of Topical Minoxidil. 3 drops Keeps 5% (3.75mg) 2x per day with comparison.

in Update 2 years ago

CumShotDiva's update on using topical minoxidil orally in an attempt to regrow hair, which has been met with both support and criticism from other users. The conversation includes discussion of possible side effects and the efficacy of this approach.

community 6 week update fellas, 5mg oral minoxidil. Pics are 2nd June – 10th July

in Progress Pictures 2 years ago

, you can find it online with a script This user was discussing their progress with hair loss treatments including 5mg oral Minoxidil and combining 3mg oral Minoxidil with MTF HRT. They also discussed side effects of increased body hair in other parts of the body.

community What regimen do I need to get this hairline?

in Satire 362 upvotes 1 year ago

Discussing a regimen to improve the user's hairline, with treatments proposed including minoxidil, rectal microneedling, IV drip of minoxidil, laser removal, PRP injection, topical minoxidil, divine protein shakes, stem cell injections, and keto shampoo.

community Starting to doubt how effective oral minoxidil is. Loniten / Loxidil Forte

in Minoxidil 5 upvotes 2 years ago

User doubts oral minoxidil's effectiveness after a month of use and shedding. Few people provide photo evidence of success, and some combine it with other treatments, making it hard to determine its effectiveness alone.

community New study shows that microneedling is an ineffective hair loss treatment

in Research/Science 1 year ago

The effectiveness of microneedling as a hair loss treatment, with evidence from studies and anecdotal accounts from other users. It is suggested that combining microneedling with minoxidil or finasteride may be more effective than using microneedling alone, although some people have had success using only microneedling.

Related Research

3 / 3 results