STIM1 R304W in Mice Causes Subgingival Hair Growth and Increased Trabecular Bone Fraction

    November 2019 in “ Cell calcium ”
    Thilini H Gamage, Emma Lengle, Gjermund Gunnes, Helen Pullisaar, Asbjørn Holmgren, Janne Elin Reseland, Else Merckoll, Stefania Corti, Masahiro Mizobuchi, Raúl Juntas Morales, Leonidas Tsiokas, Geir E. Tjønnfjord, Rodrigo S. Lacruz, Ståle Petter Lyngstadaas, Doriana Misceo, Eirik Frengen
    Image of study
    TLDR The STIM1 R304W mutation in mice leads to bone changes and teeth hair growth.
    In a study from 2020, researchers investigated the effects of the STIM1 R304W mutation, associated with Stormorken syndrome in humans, by creating a mouse model. The homozygous Stim1R304W/R304W mice exhibited perinatal lethality, with only three surviving into adulthood, showing reduced growth, low body weight, and thoracic kyphosis. Radiographs indicated a reduced number of ribs, and microcomputed tomography showed decreased cortical bone thickness but increased trabecular bone volume fraction, leading to thinner and more compact bone compared to wild type mice. Histological analysis revealed abnormal bone architecture with an increased number of trabeculae and a reduced bone marrow cavity. Additionally, a novel phenotype of bilateral subgingival hair growth on the lower incisors was observed in the homozygous mice and 25% of the heterozygous mice. These findings underscore the significant role of the gain-of-function STIM1 R304W protein in skeletal development and suggest it may also influence abnormal epithelial cell fate.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 15 results

      community Tropical growth stimulants other than minoxidil

      in Treatment  11 upvotes 6 months ago
      The conversation discusses alternative hair growth treatments to minoxidil, including Stemoxydine, Tretinoin, adenosine, Baicalin, castor oil, Latanoprost/bimatoprost, and Redensyl. Users share their experiences and opinions on the efficacy of these treatments.

      community Began An Intensive Protocol but it's now all habit.

      in Hair Systems  2 upvotes 2 years ago
      The user follows an intensive hair loss protocol including dutasteride, biotin, black tea, pumpkin seed oil, peppermint shampoo, rosemary conditioner, mukemame, soy milk, lycopene, garlic, magnesium, chamomile, spicy food, citrus bergamot, zinc, multivitamins, kefir, and Greek yogurt. They plan to alternate between pumpkin seed oil and safflower oil and will share before and after pictures.

      community I think we all hop on estrogen. It's the only angle

      in Satire  83 upvotes 4 months ago
      The conversation humorously discusses hair loss treatments, including Minoxidil, finasteride, RU58841, and topical 17 alpha estradiol, with some users joking about transitioning to female to avoid baldness. The overall tone is satirical, emphasizing self-acceptance and the lengths people might consider for hair restoration.

      community Progress? Trying to fill in this crown.

      in Progress Pictures  22 upvotes 8 months ago
      The user has been treating hair loss with finasteride, minoxidil, microneedling, Nizoral shampoo, and Nutrafol, and is asking for opinions on their progress. Suggestions include continuing current treatments, considering dutasteride or other options, and being cautious with microneedling frequency to avoid scar tissue.

    Similar Research

    5 / 973 results