STIM1, But Not STIM2, Is the Calcium Sensor Critical for Sweat Secretion

April 2018 in “ Journal of Investigative Dermatology ”

Chongwei Cui, Ji Heon Noh, Mary Ellen Michel, Myriani Gorospe, David Schlessinger

hair follicle stem cells alopecia areata troponin I sensitive scalps sebum production microbiome keratin network cornification STIM1 calcium sensor sweat secretion sweat glands hair growth peptide egg yolk VEGF female pattern hair loss AA FPHL

TLDR STIM1 is essential for sweat secretion.

The document presents several abstracts from scientific studies related to skin biology and hair growth. One study found that external light can activate hair follicle stem cells through a neural circuit involving the eyes, which may facilitate rapid adaptive responses to light in tissues. Another study reported that individuals with alopecia areata (AA) have significantly increased blood plasma levels of the cardiac biomarker troponin I, suggesting a potential link between AA and heart tissue remodeling. A different study observed that sensitive scalps have altered biophysical properties, increased sebum production, and a disturbed microbiome, which could inform treatment strategies. Additionally, live imaging revealed dynamic changes in the keratin network during cornification in mice, which is associated with skin barrier function. A key finding from another study is that STIM1, not STIM2, is the critical calcium sensor for sweat secretion in sweat glands. Lastly, a study discovered a hair growth peptide derived from egg yolk that stimulates VEGF production and improves hair growth, which could be beneficial for treating female pattern hair loss (FPHL).

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