Whole-Genome Sequencing of Eight Goat Populations for the Detection of Selection Signatures Underlying Production and Adaptive Traits

    December 2016 in “ Scientific Reports ”
    Xiaolong Wang, Jing Liu, Guangxian Zhou, Jiazhong Guo, Hailong Yan, Yaxiao Niu, Yan Li, Chao Yuan, Rong Geng, Xianyong Lan, Xiaopeng An, Xingui Tian, Huangkai Zhou, Jiuzhou Song, Yu Jiang, Yulin Chen
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    TLDR Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.
    In the 2016 study, researchers sequenced the genomes of eight goat breeds and found approximately 10 million SNPs per breed, identifying 22 genomic regions associated with traits like coat color, body size, cashmere production, and high altitude adaptation. Key genes such as ASIP, KITLG, HTT, GNA11, OSTM1, TBX15, DGCR8, CDC25A, RDH16, LHX2, FGF9, WNT2, CDK2, SOCS2, NOXA1, and ENPEP were implicated in these traits. The study also highlighted breed-specific SNPs in conserved regions, suggesting a role for regulatory variants in trait development. This research enhances understanding of the genetic basis for phenotypic variation in goats and could inform future genetic improvement strategies.
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