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    Glossary Calcineurin Inhibitors

    medications that suppress immune response by blocking calcineurin activity

    Calcineurin inhibitors (CNIs) are a class of medications that suppress the immune system by blocking the activity of calcineurin, a protein involved in activating T-cells. They are commonly used to prevent organ transplant rejection and to treat autoimmune diseases. In dermatology, CNIs like tacrolimus and pimecrolimus are used topically to manage conditions such as atopic dermatitis and certain types of alopecia, as they help reduce inflammation and immune response in the skin.

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    Research 30 of 762

    1. The Many Faces of Calcineurin Inhibitor Toxicity—What the FK? Advances in chronic kidney disease · 2020 · 97 citations
    2. Endocrine effects of long-term calcineurin inhibitor use in solid organ transplant recipients European Journal of Endocrinology · 2025 · 7 citations
    3. Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus Biologics: Targets & Therapy · 2011 · 9 citations
    4. Scalp atrophy secondary to steroid use in patients with scarring alopecia: are topical steroids superior to topical calcineurin inhibitors? International Journal of Dermatology · 2023 · 1 citations
    5. Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma International journal of dermatology and venereology · 2019
    6. Effect of immunosuppressive ppiase inhibitors, cyclosporin A, FK506, ascomycin and rapamycin on hair growth initiation Journal of dermatological science · 1994
    7. British Association of Dermatologists’ guidelines for the management of alopecia areata 2012 British Journal of Dermatology · 2012 · 218 citations
    8. Psoriasis treatment in difficult locations: scalp, nails, and intertriginous areas Clinics in Dermatology · 2008 · 104 citations
    9. Vitiligo - Part 2 - classification, histopathology and treatment Anais Brasileiros de Dermatologia · 2014 · 78 citations
    10. Safety of dermatologic medications in pregnancy and lactation Journal of The American Academy of Dermatology · 2014 · 73 citations
    11. Management of congenital ichthyoses: European guidelines of care, part two British Journal of Dermatology · 2018 · 66 citations
    12. Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment American Journal of Clinical Dermatology · 2019 · 61 citations
    13. Review article: dermatological complications of immunosuppressive and anti-TNF therapy in inflammatory bowel disease Alimentary Pharmacology & Therapeutics · 2013 · 60 citations
    14. Repigmentation through Melanocyte Regeneration in Vitiligo Dermatologic clinics · 2017 · 39 citations
    15. Scalp Pruritus: Review of the Pathogenesis, Diagnosis, and Management BioMed Research International · 2019 · 37 citations
    16. Central centrifugal cicatricial alopecia: challenges and solutions Clinical, Cosmetic and Investigational Dermatology · 2016 · 37 citations
    17. Cutaneous lupus erythematosus: clinico-pathologic correlation Italian Journal of Dermatology and Venereology · 2018 · 33 citations
    18. Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence Clinical, Cosmetic and Investigational Dermatology · 2021 · 19 citations
    19. Frontal fibrosing alopecia: efficacy of treatment modalities International Journal of Women's Health · 2019 · 14 citations
    20. Vitiligo: an evidence-based update. Report of the 13th Evidence Based Update Meeting, 23 May 2013, Loughborough, U.K. British Journal of Dermatology · 2013 · 12 citations
    21. Pimecrolimus interferes the therapeutic efficacy of human mesenchymal stem cells in atopic dermatitis by regulating NFAT-COX2 signaling Stem Cell Research & Therapy · 2021 · 11 citations
    22. Frontal Fibrosing Alopecia: An Update on Epidemiology and Treatment Actas Dermo-Sifiliográficas · 2015 · 7 citations
    23. Hair Transplantation for Frontal Fibrosing Alopecia: Part of the Solution? Actas Dermo-Sifiliográficas · 2015 · 7 citations
    24. Acne keloidalis nuchae in renal transplant patients receiving tacrolimus and sirolimus Australasian journal of dermatology · 2016 · 6 citations
    25. Understanding the Mechanism of Repigmentation in Vitiligo 2006 · 6 citations
    26. Advanced Therapy Medicinal Products in Vitiligo; Current Status, Future Prospect, and Approved Treatments. PubMed · 2023 · 5 citations
    27. Frontal fibrosing alopecia: efficacy of treatment modalities DOAJ (DOAJ: Directory of Open Access Journals) · 2019 · 4 citations
    28. Recent Insight on the Management of Lupus Erythematosus Alopecia Clinical, Cosmetic and Investigational Dermatology · 2021 · 3 citations
    29. Update on Frontal Fibrosing Alopecia Actas Dermo-Sifiliográficas · 2017 · 2 citations
    30. Enhanced Insights into Frontal Fibrosing Alopecia: Advancements in Pathogenesis Understanding and Management Strategies Dermatology and Therapy · 2024 · 1 citations