CAQ Corner: Basic Concepts of Transplant Immunology

    May 2022 in “ Liver transplantation ”
    Amanda Cheung, Josh Levitsky
    Image of study
    TLDR The document explains how the immune system reacts to organ transplants and the treatments used to prevent rejection.
    The document provides a comprehensive overview of transplant immunology, focusing on the immune system's response to organ transplantation, especially liver transplantation. It explains the role of the immune system, composed of innate and adaptive immunity, in recognizing foreign molecules and responding to organ transplantation. The document discusses two types of rejection: T cell–mediated rejection (TCMR) and antibody-mediated rejection (AMR), and the concept of immune tolerance. It also covers various immunosuppressive agents used to prevent organ rejection, including corticosteroids, antibody therapies, calcineurin inhibitors (CNIs), mTOR inhibitors, and antimetabolites. The document highlights the complex interplay between the innate and adaptive immune systems in response to organ transplantation, the role of T cell activation, and the pathways of TCMR and AMR. It also mentions FK-506 as the preferred first-line agent for maintenance immunosuppression and potential drug interactions with CNIs and mTOR inhibitors.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 228 results

      community Just found out I am Vitamin D deficient

      in Treatment  58 upvotes 3 years ago
      A user found out they are vitamin D deficient and was prescribed high-dose vitamin D supplements, asking if others had similar experiences and if it improved their hair. Some shared improved mood and testosterone levels after treatment, while another combined vitamin D supplements with finasteride due to family history of baldness.

      community Reminder how little the average person knows about hair loss

      in Satire  642 upvotes 2 years ago
      How little the average person knows about hair loss and how it can be an unfairly stigmatized issue, even by people with little knowledge of it themselves. Some specific treatments that were discussed include finasteride, RU58841, dutasteride, minoxidil, pyritinol, dermarolling, and diet/lifestyle changes.

      community Comprehensive Microneedling Guide

      in Microneedling  290 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community The ultimate regiment to reverse hairloss

      in Treatment  6 upvotes 1 year ago
      The conclusion of the conversation is that the user "Shakalakaplaka" shares their comprehensive hair loss regimen, which includes various treatments targeting different pathways such as DHT, inflammation, fibrosis, immune system, testosterone, gut problems, and scalp health. The effectiveness of the regimen is not confirmed, and some users express skepticism or request before and after pictures for credibility.

    Similar Research

    5 / 1000+ results