TLDR Calcineurin inhibitors, used in kidney transplants, can cause a wide range of side effects including kidney damage and other health issues.
The document reviewed the toxicity of calcineurin inhibitors, particularly cyclosporine A and tacrolimus, highlighting their impact on cholesterol homeostasis, neurotoxicity, and other side effects. It discussed the effects of these drugs on plasma lipoprotein levels, the risk of new-onset diabetes post-transplantation, and neurotoxic effects such as reversible posterior leukoencephalopathy syndrome. Additionally, it noted that cyclosporine A could induce hair growth by inhibiting calcineurin-dependent activation of NFAT in follicular keratinocytes, while tacrolimus was associated with alopecia in some transplant recipients.
57 citations,
June 2003 in “American Journal of Physiology-cell Physiology” Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.
30 citations,
January 1999 in “Dermatology” Cyclosporine A can help some people with severe alopecia areata regrow hair.
Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.
2 citations,
January 2014 in “Springer eBooks” The book details skin conditions in older adults, their link to mental health, cancer treatment importance, hair loss remedies, and managing autoimmune and itchy skin.
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December 2022 in “Cells” Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.
May 2023 in “Frontiers in Endocrinology” Thyroid disease can cause skin, hair, and nail problems, and treating the thyroid condition often improves these symptoms.
May 2024 in “Journal of Education, Health and Sport” Current treatments for folliculitis decalvans include antibiotics, isotretinoin, and potential new therapies like botulinum toxin A and PRP.
