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    Glossary Calcineurin

    enzyme crucial for activating T-cells in immune response

    Calcineurin is an enzyme that plays a crucial role in activating T-cells, which are essential for the immune response. It is involved in various cellular processes, including the regulation of hair growth, and is a target for certain immunosuppressive drugs used to treat conditions like alopecia areata, where the immune system attacks hair follicles.

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    Research 30 of 786

    1. The Many Faces of Calcineurin Inhibitor Toxicity—What the FK? Advances in chronic kidney disease · 2020 · 97 citations
    2. Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes American Journal of Physiology-cell Physiology · 2003 · 57 citations
    3. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation Genes & Development · 2014 · 40 citations
    4. Endocrine effects of long-term calcineurin inhibitor use in solid organ transplant recipients European Journal of Endocrinology · 2025 · 7 citations
    5. 1379 Cyclosporin A suppresses TGF-β2 expression via calcineurin/NFAT pathway in human dermal papilla cells Journal of Investigative Dermatology · 2023
    6. Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma International journal of dermatology and venereology · 2019
    7. Calcineurin-based immunosuppression in renal transplantation : focus on efficacy, the role of steroids, and the cardiovascular risk 2006
    8. Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus Biologics: Targets & Therapy · 2011 · 9 citations
    9. Scalp atrophy secondary to steroid use in patients with scarring alopecia: are topical steroids superior to topical calcineurin inhibitors? International Journal of Dermatology · 2023 · 1 citations
    10. The complex relationship between TFEB transcription factor phosphorylation and subcellular localization EMBO journal · 2018 · 344 citations
    11. British Association of Dermatologists’ guidelines for the management of alopecia areata 2012 British Journal of Dermatology · 2012 · 218 citations
    12. Psoriasis treatment in difficult locations: scalp, nails, and intertriginous areas Clinics in Dermatology · 2008 · 104 citations
    13. Vitiligo - Part 2 - classification, histopathology and treatment Anais Brasileiros de Dermatologia · 2014 · 78 citations
    14. Safety of dermatologic medications in pregnancy and lactation Journal of The American Academy of Dermatology · 2014 · 73 citations
    15. Frontal fibrosing alopecia: treatment with oral dutasteride and topical pimecrolimus Journal of The European Academy of Dermatology and Venereology · 2008 · 69 citations
    16. Management of congenital ichthyoses: European guidelines of care, part two British Journal of Dermatology · 2018 · 66 citations
    17. Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment American Journal of Clinical Dermatology · 2019 · 61 citations
    18. Review article: dermatological complications of immunosuppressive and anti-TNF therapy in inflammatory bowel disease Alimentary Pharmacology & Therapeutics · 2013 · 60 citations
    19. Repigmentation through Melanocyte Regeneration in Vitiligo Dermatologic clinics · 2017 · 39 citations
    20. Scalp Pruritus: Review of the Pathogenesis, Diagnosis, and Management BioMed Research International · 2019 · 37 citations
    21. Central centrifugal cicatricial alopecia: challenges and solutions Clinical, Cosmetic and Investigational Dermatology · 2016 · 37 citations
    22. Cyclosporin in dermatology: A practical compendium Dermatologic Therapy · 2020 · 36 citations
    23. Cutaneous lupus erythematosus: clinico-pathologic correlation Italian Journal of Dermatology and Venereology · 2018 · 33 citations
    24. Clinical Application of Development of Nonantibiotic Macrolides That Correct Inflammation-Driven Immune Dysfunction in Inflammatory Skin Diseases Mediators of inflammation · 2012 · 22 citations
    25. Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence Clinical, Cosmetic and Investigational Dermatology · 2021 · 19 citations
    26. Frontal fibrosing alopecia: efficacy of treatment modalities International Journal of Women's Health · 2019 · 14 citations
    27. Vitiligo: an evidence-based update. Report of the 13th Evidence Based Update Meeting, 23 May 2013, Loughborough, U.K. British Journal of Dermatology · 2013 · 12 citations
    28. Pimecrolimus interferes the therapeutic efficacy of human mesenchymal stem cells in atopic dermatitis by regulating NFAT-COX2 signaling Stem Cell Research & Therapy · 2021 · 11 citations
    29. Frontal Fibrosing Alopecia: An Update on Epidemiology and Treatment Actas Dermo-Sifiliográficas · 2015 · 7 citations
    30. Hair Transplantation for Frontal Fibrosing Alopecia: Part of the Solution? Actas Dermo-Sifiliográficas · 2015 · 7 citations