Kojyl Cinnamate Ester Derivatives Increase Adiponectin Expression and Stimulate Adiponectin-Induced Hair Growth Factors in Human Dermal Papilla Cells

The study from April 15, 2019, found that kojyl cinnamate ester derivatives (KCEDs), specifically KCED-1 and KCED-2, were effective in increasing adiponectin (APN) mRNA expression, APN protein secretion, and adipogenesis in human subcutaneous fat cells (hSCFs) more than Seletinoid G, a known APN inducer. Furthermore, when human dermal papilla cells were treated with the culture supernatant from KCED-treated hSCFs, there was an increase in mRNA expression of APN-induced hair growth factors such as insulin-like growth factor, hepatocyte growth factor, and vascular endothelial growth factor. The study concluded that KCED-1 and KCED-2 could promote hair growth by inducing endogenous APN production in subcutaneous fat tissues. The number of participants or samples used in the study was not mentioned.