Store-Operated Calcium Channels in Skin

    October 2022 in “ Frontiers in Physiology ”
    Declan Manning, Caroline Dart, Richard Evans
    TLDR Calcium channels are vital for normal skin function and their dysfunction can lead to skin issues.
    The document reviewed the role of store-operated calcium entry (SOCE) in skin physiology, highlighting its importance in various skin cell functions, including keratinocyte differentiation, melanogenesis, and eccrine sweat secretion. It discussed the involvement of stromal interaction molecules (STIMs) and Orai channels in mediating calcium influx, which is crucial for normal skin function. Dysfunction in these SOCE proteins was linked to several skin pathologies such as dermatitis, anhidrotic ectodermal dysplasia, hyperhidrosis, hair loss, and cancer. The review also explored the independent actions of STIM, the transient receptor potential canonical channel (TRPC) complex in keratinocytes, and the role of Orai channels in calcium-cyclic AMP signal crosstalk in melanocytes.
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