Store-Operated Calcium Channels in Skin

October 2022 in “ Frontiers in Physiology ”

Declan Manning, Caroline Dart, Richard Evans

store-operated calcium entry SOCE stromal interaction molecules STIMs Orai channels keratinocyte differentiation melanogenesis eccrine sweat secretion anhidrotic ectodermal dysplasia hyperhidrosis hair loss transient receptor potential canonical channel TRPC calcium-cyclic AMP signal crosstalk

TLDR Calcium channels are vital for normal skin function and their dysfunction can lead to skin issues.

The document reviewed the role of store-operated calcium entry (SOCE) in skin physiology, highlighting its importance in various skin cell functions, including keratinocyte differentiation, melanogenesis, and eccrine sweat secretion. It discussed the involvement of stromal interaction molecules (STIMs) and Orai channels in mediating calcium influx, which is crucial for normal skin function. Dysfunction in these SOCE proteins was linked to several skin pathologies such as dermatitis, anhidrotic ectodermal dysplasia, hyperhidrosis, hair loss, and cancer. The review also explored the independent actions of STIM, the transient receptor potential canonical channel (TRPC) complex in keratinocytes, and the role of Orai channels in calcium-cyclic AMP signal crosstalk in melanocytes.

View this study on frontiersin.org →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research TRP Channels in Skin Biology and Pathophysiology

124 citations , December 2016 in “Pharmaceuticals”

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Similar Research

5 / 1000+ results

research Tissue Resident and Follicular Treg Cell Differentiation Is Regulated by CRAC Channels

40 citations , March 2019 in “Nature Communications”

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

research Calcium Regulation of Stem Cells

25 citations , May 2020 in “EMBO reports”

Calcium is important for stem cell function and maintenance, especially in blood and skin cells.

research STIM1 R304W in Mice Causes Subgingival Hair Growth and Increased Trabecular Bone Fraction

9 citations , November 2019 in “Cell calcium”

The STIM1 R304W mutation in mice leads to bone changes and teeth hair growth.

research Drug Repurposing: Hypothesis, Molecular Aspects, and Therapeutic Applications

39 citations , April 2020 in “IntechOpen eBooks”

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

research Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress

2 citations , January 2023 in “International journal of biological sciences”

Gray hair can potentially be reversed, leading to new treatments.

Store-Operated Calcium Channels in Skin

Research cited in this study

research TRP Channels in Skin Biology and Pathophysiology

Related Community Posts Join

community Finasteride gyno experience and in dire need of advice

community M26 - 9 months after hair transplant! AMA

community If we can clone a sheep why we can't cure baldness till now

community 17 years fighting hair loss. My story

community 2 months fin, min, dermarolling, thoughts?