Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment

The review discussed the critical roles of ion channels in ovarian cancer (OC), highlighting their involvement in cancer cell proliferation, migration, metastasis, and drug resistance. Various ion channels, including voltage-gated sodium channels, potassium, calcium, chloride, and transient receptor potential channels, were implicated in OC progression and chemotherapy resistance. The study suggested that targeting these ion channels could serve as potential therapeutic strategies, with ion channel blockers showing promise in enhancing chemosensitivity and reducing tumor growth. The document emphasized the potential of repurposing existing ion channel modulators for OC treatment, though further research was needed to fully understand their mechanisms and therapeutic applications.