Anti-Graying Effect of the Extract of Pueraria Thunbergiana via Upregulation of cAMP/MITF-M Signaling Pathway

The study investigated the anti-graying effects of Pueraria thunbergiana (PT) extract and its active compound, puerarin, focusing on their ability to stimulate melanogenesis through the cAMP/MITF-M signaling pathway in vitro. Additionally, the research examined the prevention of follicular depigmentation in a hair cycle-accelerated hair graying mouse model. Puerarin, a major active ingredient of P. thunbergiana, is known for its therapeutic effects on various conditions such as hypertension and diabetes, and its molecular mechanism involves scavenging reactive oxygen species. The findings suggested that PT extract and puerarin could potentially maintain hair pigmentation and prevent graying.