Anti-Graying Effect of the Extract of Pueraria Thunbergiana via Upregulation of cAMP/MITF-M Signaling Pathway
August 2014
in “
Journal of dermatological science
”
Studysummary This study found that puerarin, derived from Pueraria thunbergiana, may stimulate melanogenesis and prevent follicular depigmentation in a hair graying mouse model.
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The study investigated the anti-graying effects of the extract of Pueraria thunbergiana, focusing on its impact on the cAMP/MITF-M signaling pathway. The researchers found that the extract upregulated this pathway, which is crucial for melanogenesis, the process responsible for hair pigmentation. The findings suggested that Pueraria thunbergiana extract could potentially be used to prevent or reduce hair graying by enhancing melanocyte activity and melanin production. This conclusion was supported by experimental data showing increased expression of melanogenesis-related genes and proteins in treated cells.
