TLDR Brentuximab may cause hair to regain color.
A case was reported where a patient experienced hair repigmentation while undergoing treatment with brentuximab vedotin, an antibody-drug conjugate used for treating refractory Hodgkin lymphoma and systemic anaplastic large cell lymphoma. This was notable as no prior reports had documented changes in hair pigmentation associated with brentuximab, despite its known adverse effects, which included neutropenia, peripheral sensory neuropathy, and others. This observation suggested a potential new side effect of brentuximab that warranted further investigation.
17 citations
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January 2015 in “Dermatology online journal” A patient's grey hair regained color during treatment with adalimumab.
25 citations
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March 2012 in “Journal of oncology pharmacy practice” An 81-year-old man's white hair began to regain its original color while he was treated with lenalidomide, suggesting that graying hair might be reversible.
127 citations
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November 2010 in “Pigment cell & melanoma research” We need more research on human hair follicle pigmentation, not just mouse models.
75 citations
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January 2009 in “International journal of trichology” Hair grays due to oxidative stress and fewer functioning melanocytes.
2 citations
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January 2023 in “International journal of biological sciences” Gray hair can potentially be reversed, leading to new treatments.
1 citations
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March 2019 in “Actas Dermo-Sifiliográficas” New cancer treatments are less harmful to hair but can still cause hair loss, color, shape, and growth changes.
Chemotherapy can cause skin issues and hair loss, and this guide explains how to manage them.
January 2019 in “Springer eBooks” Some chemicals and drugs can cause hair loss, which usually grows back after stopping the treatment.
10 citations
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February 2015 in “Clinics in Dermatology” The document concludes that changes in eyelashes and eyelid skin can indicate various local and systemic diseases.
