Molecular Heterogeneity of Quiescent Melanocyte Stem Cells Revealed by Single-Cell RNA-Sequencing

    December 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Joseph W. Palmer, Nilesh Kumar, Luye An, Andrew C. White, M. Shahid Mukhtar, Melissa L. Harris
    Image of study
    TLDR Different types of inactive melanocyte stem cells exist with unique characteristics and potential to develop into other cells.
    Using single-cell RNA sequencing (scRNA-seq) on KIT+/CD45- cells isolated from the telogen skin of adult female C57BL/6J mice, researchers have provided a detailed transcriptional profile of quiescent melanocyte stem cells (qMcSCs). The study confirmed known molecular signatures of qMcSC subpopulations and discovered new ones, including two with different immune privilege statuses. It also predicted the differentiation potential and quiescence depth within these subpopulations. The findings reveal that qMcSCs are a heterogeneous group, suggesting that future research should account for changes in subpopulation composition. This high-resolution map of qMcSCs during quiescence contributes to our understanding of stem cell heterogeneity and offers a valuable resource for studying cellular quiescence in stem cells in general and melanocyte stem cells in particular.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 16 results

      community Is there any new drug that looks promising ?

      in Research/Science  25 upvotes 1 year ago
      The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

      community Growing hair witch capsaicin and occasional topical minoxidil

      in Progress Pictures  58 upvotes 1 week ago
      A user shared their experience using capsaicin from chili peppers and occasional topical minoxidil to promote hair growth, noting noticeable improvements without significant side effects. They previously experienced side effects from dutasteride and minoxidil but found the new regimen effective and manageable.

      community Great news recently for people with hairloss!

      in Research/Science  113 upvotes 9 months ago
      A potential treatment for alopecia involving a protein that calms hair follicles has shown promise in rats, but skepticism remains about its applicability to humans. Many users express doubt about the timeline for effective hair loss treatments, comparing it to past unfulfilled promises.

    Related Research

    1 / 1 results