Building Epithelial Tissues From Skin Stem Cells

The document discussed the role of skin stem cells in maintaining epidermal homeostasis, hair regeneration, and wound repair. It explored the properties of these stem cells, their establishment during embryogenesis, and their ability to construct tissues with distinct architectures. The study also examined how stem cells balance proliferation and differentiation, and the link between skin cancer and mutations affecting stem cell regulation. Over the past 5 years, significant progress was made in purifying and understanding the molecular properties of skin stem cells, with the document highlighting contributions from the authors' laboratory to this expanding field.