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research The stem cell quiescence and niche signaling is disturbed in the hair follicle of the hairpoor mouse, an MUHH model mouse

2 citations , May 2022 in “Stem cell research & therapy”

This study found that hair follicle stem cells in the hairpoor mouse, a model for Marie-Unna hypotrichosis, lose their quiescent state, leading to a disordered hair cycle and contributing to alopecia.

research Dermal niche signaling and epidermal stem cells

January 2019 in “Advances in stem cells and their niches”

This review outlines the various fibroblast subsets in the skin dermis, their origins, and their influence on epidermal stem cell behavior, highlighting the role of the local dermal niche in stem cell plasticity.

research 687 BMP signaling in the hair follicle stem cell niche regulates hair growth and skin pigmentation

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that Sox2 and BMP signaling may be key regulators of pigmentation and melanocyte migration, as suggested by experiments in mice, human biopsies, and cell co-cultures.

research The Stem Cell Quiescence and Niche Signaling is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse.

October 2021 in “Research Square (Research Square)”

This study found that in hairpoor mice, disruptions in hair follicle stem cell quiescence and signaling pathways lead to disturbed hair cycles, which may help explain alopecia development in Marie-Unna Hypotrichosis patients.

research Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state

25 citations , June 2022 in “Developmental cell”

In this study, Hedgehog signaling in dermal papilla fibroblasts was found to accelerate hair growth and induce follicle multiplication in mice via the SCUBE3/TGF-β pathway, with some effects observed in human scalp hair follicles.

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community The Real Reason For Hair Loss?

8 months ago

Hair loss is linked to scalp fibrosis and tension, which result from chronic mechanical stress and androgenic signaling. Treatments include blocking androgens with finasteride, promoting hair growth with topical minoxidil, and improving scalp mobility through exercises.

community My progress with various products and without oral fin or oral dut on 17 months

in Progress Pictures 62 upvotes 1 year ago

The user shared their hair loss treatment progress using topical products like exosomes, fluridil, Kx826, and topical dutasteride, avoiding oral finasteride and dutasteride due to side effects. They found exosomes from Creative Biolabs most effective and also used topical probiotics, noting improvements without significant side effects.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community Tretinoin vs. micro-needling: what increases sulfotransferase activity more?

in Research/Science 1 upvotes 1 year ago

Tretinoin and microneedling both enhance hair growth through different mechanisms, with microneedling being considered safe for long-term use. Optimal microneedling needle length varies, but 0.8 mm is suggested for hair growth, and a Dermastamp is recommended to avoid skin damage.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Thymosin Beta 4

learn Argan oil

Argan oil: Is it useful for androgenic alopecia, or just for making hair look nice? Argan oil primarily improves hair appearance but lacks proven effectiveness for androgenic alopecia.

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Clinics

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