Extrarenal Expression of 25-Hydroxyvitamin D3-1α-Hydroxylase
February 2001
in “
The Journal of Clinical Endocrinology & Metabolism
”
New to Vitamin D? There is a guide in the encyclopedia. Read the guide → Studysummary This study identified the presence of the enzyme 1 alpha-hydroxylase in various extrarenal tissues, suggesting its potential role in modulating vitamin D function in peripheral tissues.
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The study from 2001 investigated the extrarenal expression of the enzyme 25-hydroxyvitamin D(3)-1 alpha-hydroxylase, which is crucial for vitamin D activation and calcium homeostasis. While traditionally associated with the kidney, this enzyme was also found in various extrarenal tissues, including skin, lymph nodes, colon, pancreas, adrenal medulla, brain, and placenta. Notably, increased expression was observed in psoriatic skin and sarcoidosis, particularly in CD68-positive macrophages. The findings confirmed the presence of 1 alpha-hydroxylase protein in these tissues, suggesting its potential role as an intracrine modulator of vitamin D function outside the kidneys, although its specific functions in these novel sites were yet to be determined.
