1α,25-Dihydroxyvitamin D3/VDR Protects the Skin from UVB-Induced Tumor Formation by Interacting with the β-Catenin Pathway

    September 2012 in “ The Journal of Steroid Biochemistry and Molecular Biology ”
    Jiang, Yan J., Teichert, Arnaud E., Fong, Frankie … Bikle, Daniel D.
    Studysummary This study found that deleting β-catenin in epidermis-specific VDR knockout mice did not prevent UVB-induced skin tumors, indicating β-catenin does not compensate for VDR's role in tumor suppression.
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    Research cited in this study 5

    1. Overexpression of Hedgehog Signaling Is Associated With Epidermal Tumor Formation in Vitamin D Receptor-Null Mice Journal of Investigative Dermatology · 2011
    2. Deciphering the Function of Canonical Wnt Signals in Development and Disease: Conditional Loss- and Gain-of-Function Mutations of β-Catenin in Mice Genes & Development · 2008
    3. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    4. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008
    5. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007