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GlossaryHairless Protein (HR protein)

regulates hair growth and follicle cycling

The Hairless Protein, also known as the HR protein, is a crucial component in the regulation of hair growth and development. It is encoded by the HR gene, and mutations in this gene can lead to conditions like alopecia universalis, where individuals lose all body hair. This protein plays a role in the hair follicle cycle, particularly in the transition from the growth phase (anagen) to the rest phase (telogen).

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research Poly(rC) Binding Protein 2 Acts as a Negative Regulator of IRES-Mediated Translation of Hr mRNA

3 citations, February 2018 in “Experimental and Molecular Medicine/Experimental and molecular medicine”

A protein called PCBP2 controls the production of a hair growth protein by interacting with its genetic message and is linked to hair loss when this control is disrupted.

research The Mammalian Hairless Protein as a DNA Binding Phosphoprotein

6 citations, June 2016 in “Journal of cellular biochemistry”

The Hr protein binds to DNA, interacts with p53, and affects cell cycle genes.

research Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling

137 citations, September 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

research Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation

74 citations, September 2006 in “Cell Cycle”

The HR protein's role as a repressor is essential for controlling hair growth.

research Hairless Up-Regulates TGF-β2 Expression via Down-Regulation of miR-31 in the Skin of Hairpoor (HrHp) Mice

11 citations, January 2015 in “Journal of cellular physiology”

HR protein causes abnormal hair cycles by increasing Tgf-β2 and reducing miR-31.

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community Does whey protein and creatine aggravate hair loss?

in Research/Science 82 upvotes 1 year ago

The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

community What regimen do I need to get this hairline?

in Satire 364 upvotes 1 year ago

Discussing a regimen to improve the user's hairline, with treatments proposed including minoxidil, rectal microneedling, IV drip of minoxidil, laser removal, PRP injection, topical minoxidil, divine protein shakes, stem cell injections, and keto shampoo.

community + 5 years Finasteride and dermarroll journey PICS and ACTUAL DILEMMA

in Progress Pictures 54 upvotes 10 months ago

The user experienced improved hair density and thickness after using finasteride and dermarolling for 2.5 years but noticed hair loss when doing anaerobic exercise. They increased their finasteride dose and continued dermarolling but are considering not starting minoxidil due to its perceived hassle and uncertain long-term benefits.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 5 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Creatine's effect on Hair Loss and DHT

in Research/Science 99 upvotes 11 months ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

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