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GlossaryHairless Protein (HR protein)

regulates hair growth and follicle cycling

The Hairless Protein, also known as the HR protein, is a crucial component in the regulation of hair growth and development. It is encoded by the HR gene, and mutations in this gene can lead to conditions like alopecia universalis, where individuals lose all body hair. This protein plays a role in the hair follicle cycle, particularly in the transition from the growth phase (anagen) to the rest phase (telogen).

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research Poly(rC) Binding Protein 2 Acts as a Negative Regulator of IRES-Mediated Translation of Hr mRNA

3 citations , February 2018 in “Experimental and Molecular Medicine/Experimental and molecular medicine”

A protein called PCBP2 controls the production of a hair growth protein by interacting with its genetic message and is linked to hair loss when this control is disrupted.

research The 'Bald Mill Hill' Mutation in the Mouse Is Associated with an Abnormal, Mislocalized HR BMH Protein

1 citations , July 2007 in “Journal of Investigative Dermatology”

The mutation causes hairless mice due to mislocalized and dysfunctional HR protein.

research The Abnormal, Mislocalized HR BMH Protein Associates with Members of the Protein Processing Machinery in the Cytoplasm

January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

The mutant HR bmh protein mis-localizes in cells, affecting skin and hair development.

research The Mammalian Hairless Protein as a DNA Binding Phosphoprotein

6 citations , June 2016 in “Journal of cellular biochemistry”

The Hr protein binds to DNA, interacts with p53, and affects cell cycle genes.

research Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling

137 citations , September 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

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community Does whey protein and creatine aggravate hair loss?

in Research/Science 81 upvotes 2 years ago

The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

community What regimen do I need to get this hairline?

in Satire 362 upvotes 2 years ago

Discussing a regimen to improve the user's hairline, with treatments proposed including minoxidil, rectal microneedling, IV drip of minoxidil, laser removal, PRP injection, topical minoxidil, divine protein shakes, stem cell injections, and keto shampoo.

community + 5 years Finasteride and dermarroll journey PICS and ACTUAL DILEMMA

in Progress Pictures 54 upvotes 1 year ago

The user experienced improved hair density and thickness after using finasteride and dermarolling for 2.5 years but noticed hair loss when doing anaerobic exercise. They increased their finasteride dose and continued dermarolling but are considering not starting minoxidil due to its perceived hassle and uncertain long-term benefits.

community 4 months, only Minoxidil 5% ,dermarolling twice a week. hair growth results. any suggestions?

in Minoxidil 459 upvotes 7 months ago

Significant hair growth was achieved using Minoxidil 5% and dermarolling twice a week, with suggestions to add finasteride for maintenance. There is debate on when to apply Minoxidil after dermarolling to avoid irritation.

community 1 year 1 month 1mg finasteride 2.5mg oral minoxidil (eyebrow + scalp gains)

in Progress Pictures 178 upvotes 8 months ago

The conversation is about a user's positive experience with hair regrowth using 1mg finasteride and 2.5mg oral minoxidil, noting improvements in scalp and eyebrow hair. The user mentions minimal side effects, such as a slight increase in heart rate, and prefers oral minoxidil over topical due to ease of use.

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