Poly(rC) Binding Protein 2 Acts as a Negative Regulator of IRES-Mediated Translation of Hr mRNA

    February 2018 in “ Experimental and Molecular Medicine/Experimental and molecular medicine ”
    Jeong-Ki Kim, In Jung Kim, Kyu-Yong Choi, Ji-Hyeok Choi, Eunmin Kim, Hwa Young Lee, Jong‐Keun Park, Sungjoo Kim Yoon
    TLDR A protein called PCBP2 controls the production of a hair growth protein by interacting with its genetic message and is linked to hair loss when this control is disrupted.
    The study demonstrated that Poly(rC) binding protein 2 (PCBP2) acted as a negative regulator of internal ribosome entry site (IRES)-mediated translation of hairless (Hr) mRNA. PCBP2 bound to the 5′ untranslated region (UTR) of Hr mRNA, inhibiting HR protein expression without altering mRNA levels. Overexpression of PCBP2 decreased IRES activity and HR protein levels, while knockdown increased them. This regulation was disrupted in mutant Hr 5′ UTR associated with Marie Unna hereditary hypotrichosis (MUHH), leading to abnormal HR protein overexpression. These findings suggested that modulating PCBP2 activity could be a potential therapeutic strategy for hair loss conditions like alopecia.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 18 results

      community Started going bald at 21, I’m 32 Now and Decided to Try a Hair Piece.

      in Hair Systems  675 upvotes 5 years ago
      A user who has started to go bald and decided to try wearing a hair piece, discussing the experience of doing so and sharing tips for maintenance. The conversation includes discussion about confidence in relation to wearing a wig or hair piece, as well as advice on getting it cut and attached professionally.

      community Before, and my last 3 hair styles over 2 years. (Hair system)

      in Hair Systems  537 upvotes 1 year ago
      A user shared their experience with hair loss, initially using finasteride and minoxidil without satisfactory results, and later switching to hair systems, which they plan to use indefinitely. The user and others discussed the positive reactions, maintenance, and normalization of hair systems for men.

      community Could you tell this is a hair system?

      in Technology  307 upvotes 3 years ago
      A user who was losing their hair and found an effective solution; they asked for opinions on it and discussed treatments such as Minoxidil, Finasteride, and RU58841, as well as SMP.

      community Helicobacter's concocted serum v1

       7 upvotes 7 years ago
      A custom-made serum based on double-blind studies for AGA, which includes natural ingredients such as rosemary oil, procyanidin B-2, saw palmetto extract, curcuma aeruginosa, pumpkin seed oil and castor oil. The user has updated their recipe to include apple poly procyanidin B-2 4% concentration and other ingredients before topping it off with Pura d'or serum.

      community Novel effect of sildenafil (cialis) on hair growth

      in Research/Science  20 upvotes 3 years ago
      Sildenafil (Viagra) shows potential for hair growth by enhancing dermal papilla cell proliferation and stimulating perifollicular vessel formation. Users discuss the possibility of using Cialis (tadalafil) similarly, noting its benefits and side effects.

    Similar Research

    5 / 1000+ results