Progenitor Cell Dysfunctions Underlie Some Diabetic Complications

    June 2015 in “ American Journal Of Pathology ”
    Mélanie Rodrigues, Victor W. Wong, Robert C. Rennert, Christopher R. Davis, Michael T. Longaker, Geoffrey C. Gurtner
    TLDR Diabetes causes lasting cell dysfunctions, leading to serious complications even after blood sugar is controlled.
    The study concluded that progenitor cell dysfunctions significantly contributed to various diabetic complications by impairing tissue repair and regeneration. Diabetes-induced hyperglycemia disrupted progenitor cell functions, leading to poor wound healing, cardiovascular issues, and reduced neovascularization. Despite glycemic control, some dysfunctions persisted due to hyperglycemic memory and lasting epigenetic changes. The research emphasized the potential of targeting progenitor cell function and preconditioning stem cells with agents like deferoxamine (DFO) to improve outcomes, although challenges remained in replicating the diabetic environment in vitro and addressing genetic changes.
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