Clinical Guidelines of Ukrainian Hair Research Society: Diagnosis and Treatment of Alopecia Areata

November 2023 in “ Aktualʹnì problemi sučasnoï medicini ”

Inessa Mykhailivna Serbina, Kuzma Кhobzei, Тетяна Лядова, Oleksandr I. Litus, С. В. Возіанова, Yu.V. Andrashko, Svitlana Halnykina, T.V. Svyatenko, Igor Svistunov, Оrysya Syzon, Iryna Kadyhrob, Yuliya Ovcharenko

alopecia areata antidepressants oral cyclosporine intralesional steroid injections triamcinolone acetonide immune privilege collapse genetic aspects micronutrients methotrexate serum iron ferritin levels minoxidil ritlecitinib baricitinib hair prostheses Janus Kinase inhibitors Rogaine JAK inhibitors

TLDR The guidelines suggest using various treatments, including antidepressants and steroids, for alopecia areata and discuss the condition's genetic and immune aspects.

The document provides clinical guidelines for diagnosing and treating alopecia areata, discussing the role of psychological disorders, the burden of the disease, and current unmet needs. It highlights the use of antidepressants, oral cyclosporine, intralesional steroid injections, and different concentrations of intralesional triamcinolone acetonide in treatment. The role of immune privilege collapse and genetic aspects of the condition are also discussed. Comorbidities and the role of micronutrients in patients with alopecia areata are covered, along with the use of methotrexate, serum iron and ferritin levels, and minoxidil. The efficacy and safety of ritlecitinib and baricitinib in treatment are discussed, as well as the use of hair prostheses in severe cases. The safety of Janus Kinase inhibitors in patients with alopecia areata is also mentioned.

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Research cited in this study

33 / 33 results

research Safety of Janus Kinase Inhibitors in Patients with Alopecia Areata: A Systematic Review

3 citations , May 2023 in “Clinical drug investigation”

JAK inhibitors for alopecia areata are linked to minor side effects like headache and acne, but not to an increased risk of serious adverse events.

research Alopecia Areata: Burden of Disease, Approach to Treatment, and Current Unmet Needs

1 citations , March 2023 in “Clinical, Cosmetic and Investigational Dermatology”

Current treatments for Alopecia Areata have mixed success, and there's a need for better, more accessible options and support for affected individuals.

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations , March 2022 in “The New England Journal of Medicine”

Baricitinib was effective in treating alopecia areata in two major trials.

research Joint Study of the Associations of HLA-B and the Transmembrane Short Tandem Repeat Polymorphism of MICA Protein with Alopecia Areata Shows Independent Associations of Both with the Disease

7 citations , February 2020 in “Clinical and Experimental Dermatology”

Both HLA-B and MICA are independently linked to alopecia areata.

research Cyclosporine for Moderate-to-Severe Alopecia Areata: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety

44 citations , April 2019 in “Journal of the American Academy of Dermatology”

Cyclosporine showed some improvement in alopecia areata but results were not statistically significant.

research Role of Hair Prostheses (Wigs) in Patients with Severe Alopecia Areata

15 citations , January 2018 in “Annals of Dermatology”

Wigs significantly improve the well-being of people with severe hair loss.

research Immune Privilege Collapse And Alopecia Development: Is Stress A Factor

51 citations , December 2017 in “Skin Appendage Disorders”

Stress may trigger hair loss by affecting immune protection in hair follicles.

research Alopecia Areata: A Comprehensive Review of Pathogenesis and Management

99 citations , July 2017 in “Clinical Reviews in Allergy & Immunology”

New treatments for Alopecia Areata show promise but need to be more effective and affordable.

research Methotrexate for the Treatment of Pediatric Alopecia Areata

22 citations , June 2017 in “Journal of dermatological treatment”

Methotrexate is generally safe and often effective for treating hair loss in children.

research The Role of Micronutrients in Alopecia Areata: A Review

63 citations , May 2017 in “American Journal of Clinical Dermatology”

People with alopecia areata often have lower levels of vitamin D, zinc, and folate, but more research is needed to understand if supplements can help treat it.

research Best Dilution of the Best Corticosteroid for Intralesional Injection in the Treatment of Localized Alopecia Areata in Adults

22 citations , May 2017 in “Journal of dermatological treatment”

BD 1/4 dilution is the best for treating localized alopecia areata in adults.

research Changes of Serum Trace Elements Level in Patients with Alopecia Areata: A Meta-Analysis

23 citations , February 2017 in “Journal of dermatology”

Low serum levels of zinc and selenium may increase the risk of alopecia areata.

research Syphilitic Alopecia: Case Reports and Trichoscopic Findings

29 citations , January 2017 in “Skin appendage disorders”

Hair loss due to syphilis can be identified using trichoscopy and is treatable with antibiotics.

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128 citations , February 2016 in “British Journal of Dermatology”

Alopecia areata significantly lowers the quality of life, especially in emotional and mental health aspects.

research Biomarkers of Alopecia Areata Disease Activity and Response to Corticosteroid Treatment

65 citations , December 2015 in “Experimental dermatology”

Corticosteroid treatment reduces inflammation and alters hair keratins in alopecia areata.

research Benefit of Different Concentrations of Intralesional Triamcinolone Acetonide in Alopecia Areata: An Intrasubject Pilot Study

50 citations , July 2015 in “Journal of the American Academy of Dermatology”

Using 2.5 mg/mL triamcinolone acetonide is effective for hair growth in alopecia areata with fewer side effects.

research Epidemiology and Burden of Alopecia Areata: A Systematic Review

144 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.

research Methotrexate in Severe Childhood Alopecia Areata: Long-Term Follow-Up

25 citations , June 2015 in “Acta dermato-venereologica”

Methotrexate can help some kids with severe hair loss regrow hair.

research The Genetics Of Alopecia Areata: New Approaches, New Findings, New Treatments

62 citations , January 2015 in “Journal of Dermatological Science”

New genetic discoveries may lead to better treatments for alopecia areata.

research Alopecia Areata as a Paraneoplastic Syndrome of Hodgkin’s Lymphoma: A Case Report

10 citations , April 2014 in “Molecular and Clinical Oncology”

Alopecia areata can be an early sign of Hodgkin’s lymphoma and may improve with lymphoma treatment.

research Minoxidil Induced Hypertrichosis in a 2-Year-Old Child

17 citations , October 2013 in “F1000Research”

A 2-year-old boy grew excessive hair after using minoxidil for hair loss, but it improved when the treatment stopped.

research The Effect of Oral Cyclosporine in the Treatment of Severe Alopecia Areata

33 citations , October 2013 in “Cutaneous and ocular toxicology”

Oral cyclosporine can help regrow hair in severe alopecia areata cases.

research The Basic Science of Hair Biology

29 citations , September 2012 in “Dermatologic Clinics”

Hair disorders are caused by a complex mix of biology, genetics, hormones, and environmental factors, affecting hair growth and leading to conditions like alopecia.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

research Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss

38 citations , February 2012 in “British Journal of Dermatology”

AR/EDA2R gene linked to early-onset female hair loss, but 20p11 gene not involved.

research Alopecia Areata: A New Treatment Plan

67 citations , July 2011 in “Clinical, cosmetic and investigational dermatology”

The document suggests a personalized treatment plan for alopecia areata based on the patient's age and hair loss severity, using a range of therapies ranked by effectiveness and safety.

research Quality of Life in Alopecia Areata: A Study of 60 Cases

44 citations , December 2010 in “Journal of Investigative Dermatology”

Alopecia areata seriously lowers quality of life, especially affecting self-image, mental health, and social life.

research Alopecia Areata Update

244 citations , January 2010 in “Journal of the American Academy of Dermatology”

The document says current treatments for alopecia areata do not cure or prevent it, and it's hard to judge their effectiveness due to spontaneous remission and lack of studies.

research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research Comma Hairs: A Dermatoscopic Marker for Tinea Capitis

143 citations , October 2008 in “Journal of The American Academy of Dermatology”

Comma hairs are a specific sign of tinea capitis when viewed with videodermatoscopy.

research Significance of Dermoscopy in Acute Diffuse and Total Alopecia of the Female Scalp: Review of Twenty Cases

42 citations , January 2008 in “Dermatology”

Dermoscopy effectively distinguishes between acute total hair loss and other types of female hair loss.

research Familial Aggregation of Alopecia Areata

295 citations , January 2006 in “Journal of the American Academy of Dermatology”

Alopecia areata, a common autoimmune hair loss condition, often runs in families.

research Alopecia Areata Incognita: A Hypothesis

60 citations , January 1987 in “Dermatology”

Alopecia areata may appear differently depending on the individual's type of hair loss and scalp condition.

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research Case Report of Novel Combination of Anthralin and Calcipotriene Leading to Trichologic Response in Alopecia Areata

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research Alopecia Areata: A Multifactorial Autoimmune Condition

148 citations , December 2018 in “Journal of autoimmunity”

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

research Linear Alopecia Areata

4 citations , November 2018 in “JAAD case reports”

Alopecia areata can sometimes appear as a straight line of hair loss instead of round patches.

research Treating Resistant Cases of Alopecia Universalis

May 2018 in “Journal of cosmetology & trichology”

Combining platelet-rich plasma therapy with prostaglandin-F eye drops can significantly regrow hair in alopecia universalis.