Alopecia Areata as a Paraneoplastic Syndrome of Hodgkin’s Lymphoma: A Case Report

April 2014 in “ Molecular and Clinical Oncology ”

Jun Gong, Stephen Lim

alopecia areata paraneoplastic syndrome Hodgkin’s lymphoma T-lymphocyte-mediated mechanisms AA HL

TLDR Alopecia areata can be an early sign of Hodgkin’s lymphoma and may improve with lymphoma treatment.

This case report described a 46-year-old male diagnosed with alopecia areata (AA) several months before the onset of B symptoms and stage IVB classical Hodgkin’s lymphoma (HL). The patient received 6 cycles of ABVD chemotherapy, resulting in complete remission of both HL and AA. The report highlighted that AA can precede or occur concurrently with HL and that treating HL often resolves AA. The etiology of AA as a paraneoplastic syndrome in HL remained unclear but was thought to involve T-lymphocyte-mediated mechanisms. This case underscored the importance of recognizing AA as a potential indicator of underlying malignancy.

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Research cited in this study

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research Hodgkin's Lymphoma Presenting as Alopecia

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Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research Rapidly Progressing Mycosis Fungoides Presenting as Follicular Mucinosis

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community Alopecia Areata Question

in Treatment 2 upvotes 3 years ago

A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

community mbp alopecia areata or vitamin deficiency

in Chat 5 months ago

A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

community Olumiant alternative for Alopecia Areata?

in Treatment 1 upvotes 1 year ago

A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

community Covid (likely) induced alopecia areata - now 2nd round of Covid, what can I expect?

in Treatment 1 upvotes 1 year ago

After experiencing hair loss due to alopecia areata following COVID-19 vaccination and infection, the individual saw improvement with steroid treatments and Olumiant. They paused Olumiant during a second COVID-19 infection and expressed concern about potential hair loss flare-ups.

community Onion Juice - An effective topical treatment for Alopecia Areata 🧬

in Treatment 1 year ago

Onion juice, when applied topically, is an effective treatment for Alopecia Areata, showing significant hair regrowth in both males and females. The study suggests it could be interesting to test its effectiveness on Androgenic Alopecia.

community Nearly 40% of Adults with Alopecia Areata Taking OLUMIANT® 4-mg Saw at Least 80% Scalp Hair Coverage at 52 Weeks

in Research/Science 6 upvotes 2 years ago

Nearly 40% of adults with alopecia areata achieved at least 80% scalp hair coverage after 52 weeks of taking OLUMIANT® 4-mg. The conversation distinguishes this success from androgenetic alopecia, which is a different type of hair loss.

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research Alopecia Areata as a Paraneoplastic Syndrome of Hodgkin’s Lymphoma: A Case Report

10 citations, April 2014 in “Molecular and Clinical Oncology”

Alopecia areata can be an early sign of Hodgkin’s lymphoma and may improve with lymphoma treatment.