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    Glossary Janus Kinase 1

    enzyme involved in immune signaling and cell growth

    Janus Kinase 1 (JAK1) is an enzyme that plays a crucial role in the signaling pathways of various cytokines, which are proteins important for immune system communication. It is part of the JAK family of tyrosine kinases and is involved in processes such as cell growth, development, and immune responses. In the context of hair and alopecia, JAK1 inhibitors are being researched as potential treatments for conditions like alopecia areata, an autoimmune disorder that causes hair loss.

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    1. Selective Janus kinase 1 inhibition resolves inflammation and restores hair growth offering a viable treatment option for alopecia areata Skin health and disease · 2023 · 4 citations
    2. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial Journal of the American Academy of Dermatology · 2025 · 2 citations
    3. 170 Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index Journal of Investigative Dermatology · 2019
    4. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    5. Determination of 13 janus kinase inhibitors in anti-alopecia cosmetics by ultra-high performance liquid chromatography-tandem triple quadrupole composite linear ion trap mass spectrometry Chinese Journal of Chromatography · 2025
    6. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients International Journal of Trichology · 2018 · 24 citations
    7. Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients Journal of the American Academy of Dermatology · 2017 · 48 citations
    8. Janus Kinase Inhibitors in Dermatology: Part 1 — General Considerations and Applications in Vitiligo and Alopecia Areata Actas Dermo-Sifiliográficas · 2021 · 14 citations
    9. Effectiveness and safety of oral Janus kinase inhibitors in patients aged ≤12 with alopecia areata: a systematic review and meta-analysis Mendeley Data · 2026
    10. Effectiveness and safety of oral Janus kinase inhibitors in patients aged ≤12 with alopecia areata: a systematic review and meta-analysis Mendeley Data · 2026
    11. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
    12. 151 Efficacy and adverse effects of oral Janus kinase inhibitor (JAKi) use in patients with lichen planopilaris: a retrospective case series and systematic review 2023
    13. The Janus kinase 1 inhibitor abrocitinib for the treatment of oral lichen planus 2023 · 7 citations
    14. The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature Journal of cutaneous medicine and surgery · 2019 · 17 citations
    15. Off-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review Archives of Dermatological Research · 2025 · 3 citations
    16. Use of oral Janus kinase inhibitors for the treatment of severe alopecia areata: narrative review and real-world experience Immunological Medicine · 2026
    17. 43046 Outcomes of Down-Titration in Patients with Severe Scalp Alopecia Areata Treated with Baricitinib 4 Mg: Week 104 Data from BRAVE-AA2 Journal of The American Academy of Dermatology · 2023
    18. 013 IL-15/IL-15Rα signaling is a guardian of human hair follicle immune privilege and promotes hair growth 2022
    19. Ann Robinson’s research reviews —12 May 2022 The BMJ · 2022
    20. Real-world Effectiveness and Safety of Janus Kinase Inhibitors in Alopecia Areata: A Retrospective Cohort Study of 72 Patients Acta Dermato Venereologica · 2025
    21. Real-Life Effectiveness and Tolerance of Baricitinib for the Treatment of Severe Alopecia Areata with 1-Year Follow-Up Data Dermatology and Therapy · 2023
    22. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    23. Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α and allergic responses Journal of Allergy and Clinical Immunology · 2021 · 59 citations
    24. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    25. Alopecia areata following COVID-19 vaccine: a systematic review European journal of medical research · 2024 · 8 citations
    26. Ruxolitinib 1.5% Topical Cream for the Treatment of Pediatric Alopecia Areata Journal of Drugs in Dermatology · 2024 · 4 citations
    27. 1313 Fzd2 controls multiple aspects of epidermal development through distinct signaling mechanisms Journal of Investigative Dermatology · 2018 · 1 citations
    28. Comparative Efficacy Evaluation of Alopecia Areata Management with Janus Kinase Inhibitors in Children: Retrospective Cohort Study Педиатрическая фармакология · 2025
    29. Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials Postgraduate Medical Journal · 2025
    30. Iron Chelators in the Management of Autoimmune-Induced Alopecia: A Focus on Hypoxia-Inducible Factor 1 Modulation and Hair Restoration Journal of Clinical Medicine · 2025