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    Glossary Janus Kinase 3

    enzyme involved in immune cell signaling pathways

    Janus Kinase 3 (JAK3) is an enzyme that plays a crucial role in the signaling pathways of certain types of immune cells. It is involved in the transmission of signals from various cytokine receptors, which are important for the development and function of the immune system. Mutations or malfunctions in JAK3 can lead to immune disorders and have been targeted in treatments for conditions like alopecia areata and rheumatoid arthritis.

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    Research 30 of 1000+

    1. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    2. <i>In‐silico</i> Screening of ATP‐competitive Inhibitory Activities of Phytochemicals against Janus Kinase 3 and Its <i>In‐vitro</i> Evaluation ˜The œFASEB journal · 2020
    3. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase inhibitor, in adults with alopecia areata: Results from the Phase 3 randomized, controlled trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024 · 63 citations
    4. 170 Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index Journal of Investigative Dermatology · 2019
    5. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    6. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial Journal of the American Academy of Dermatology · 2025 · 2 citations
    7. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients International Journal of Trichology · 2018 · 24 citations
    8. 378 Treatment of severe alopecia areata with the oral Janus kinase inhibitor, tofacitinib: A retrospective chart review Journal of Investigative Dermatology · 2017 · 1 citations
    9. BH09 Patient experience of off-label Janus kinase inhibitor use for alopecia areata in a cohort of 34 patients from a single UK practitioner: exploring changing trends in healthcare provision and access to drug treatments 2023
    10. Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib: A 32-week open-label extension study with optional narrow-band ultraviolet B Journal of the American Academy of Dermatology · 2018 · 74 citations
    11. Janus kinase inhibitors for alopecia areata Journal of the American Academy of Dermatology · 2023 · 7 citations
    12. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
    13. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    14. LB785 Efficacy and safety of baricitinib in adults with Alopecia Areata: Phase 3 results from a randomized controlled trial (BRAVE-AA1) Journal of Investigative Dermatology · 2021 · 3 citations
    15. Olumiant® (Baricitinib)-A Newly Approved Janus Kinase Inhibitor for the Treatment of Alopecia Areata. PubMed · 2022
    16. Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α and allergic responses Journal of Allergy and Clinical Immunology · 2021 · 59 citations
    17. Baricitinib Provides Higher Efficacy in Adolescents Relative to Adults With Alopecia Areata Despite More Severe Disease at Baseline: 36-Week Outcomes From BRAVE-AA Trials SKIN The Journal of Cutaneous Medicine · 2025
    18. Alopecia Areata, triggered by psychological stress and successfully treated with a Janus kinase inhibitor. Case report 2022
    19. The changing landscape of managing hair loss: a 30‐year perspective Journal of the European Academy of Dermatology and Venereology · 2021
    20. 33774 Baricitinib results in eyebrow and eyelash growth in patients with alopecia areata who do not achieve 20% or less scalp hair loss Journal of The American Academy of Dermatology · 2022 · 1 citations
    21. 32237 Clinician and patient evaluation of improvement for eyebrow and eyelashes hair loss during baricitinib phase 3 trials BRAVE-AA1 and BRAVE-AA2 Journal of The American Academy of Dermatology · 2022
    22. Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients Journal of the American Academy of Dermatology · 2017 · 48 citations
    23. 44182 Treatment with Oral Janus Kinase Inhibitors in Adults Patients with Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2023
    24. P88 Real-world evidence on efficacy and safety of Janus Kinase inhibitors in the treatment of moderate to severe active Ulcerative Colitis Poster presentations · 2024
    25. Evolution of Ritlecitinib Population Pharmacokinetic Models During Clinical Drug Development Clinical Pharmacokinetics · 2023 · 6 citations
    26. The Role of Tofacitinib in the Management of Alopecia Totalis Sultan Qaboos University Medical Journal · 2019 · 4 citations
    27. Real-world assessment of ritlecitinib in patients with severe alopecia areata: a 24-week multicentre retrospective study Clinical and Experimental Dermatology · 2025 · 3 citations
    28. 0975 Single-cell transcriptomic profiling reveals distinct immunopathogenic programs in alopecia totalis/universalis compared to patchy alopecia areata Journal of Investigative Dermatology · 2026
    29. UHPLC-Q-Orbitrap HRMS-based Metabolomics and In Silico Studies on 5-α-Reductase, JAK1, JAK2, and JAK3 of <i>Albizia saponaria</i> L.: Application to Alopecia Tropical Journal of Natural Product Research · 2026
    30. Environmental Modulation of JAK3-Mediated Immune Dysregulation in Alopecia Areata Scholarly Commons (Embry–Riddle Aeronautical University) · 2025