Recovery of Nail Dystrophy: Potential New Therapeutic Indication of Tofacitinib

February 2017 in “ Clinical rheumatology ”

Jose A. Jaller, Juan José Jaller, Antonio M. Jaller, Juan J. Jaller-Char, Sineida Berbert Ferreira, Rachel Berbert Ferreira, Morton Scheinberg

TLDR Tofacitinib may help treat nail dystrophy, especially when other treatments fail.

The document reported that tofacitinib, a therapy initially developed for rheumatoid arthritis, showed potential benefits for patients with nail dystrophy, particularly those whose condition was resistant to conventional treatments. This finding suggested a new therapeutic indication for tofacitinib in treating nail diseases associated with autoimmune conditions like psoriasis and psoriatic arthritis.

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research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

238 citations , January 2017 in “Journal of The American Academy of Dermatology”

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

research Reversal of Alopecia Universalis by Tofacitinib: A Case Report

14 citations , November 2016 in “Annals of Internal Medicine”

Tofacitinib, an arthritis drug, helped hair growth in alopecia universalis but long-term safety needs more research.

research Remarkable Improvement of Nail Changes in Alopecia Areata Universalis with 10 Months of Treatment with Tofacitinib: A Case Report

26 citations , October 2016 in “Case Reports in Dermatology”

A man with severe hair loss saw hair and nail improvement after 10 months on tofacitinib without side effects.

research Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated with Alopecia Universalis

41 citations , April 2016 in “JAMA Dermatology”

Tofacitinib citrate improved nail dystrophy and pain in patients with alopecia universalis without causing side effects.

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

185 citations , December 2014 in “Journal of Investigative Dermatology”

A man with severe hair loss and skin disease regrew his hair with no side effects after taking tofacitinib.

research Familial Aggregation of Alopecia Areata

295 citations , April 2006 in “Journal of the American Academy of Dermatology”

Alopecia areata, a common autoimmune hair loss condition, often runs in families.