Recovery of Nail Dystrophy: Potential New Therapeutic Indication of Tofacitinib

February 2017 in “ Clinical rheumatology ”

Jose A. Jaller, Juan José Jaller, Antonio M. Jaller, Juan J. Jaller-Char, Sineida Berbert Ferreira, Rachel Berbert Ferreira, Morton Scheinberg

tofacitinib nail dystrophy rheumatoid arthritis psoriasis psoriatic arthritis autoimmune conditions Xeljanz

Studysummary This report suggests that tofacitinib may be beneficial for patients with nail disease unresponsive to other treatments.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document reported that tofacitinib, a therapy initially developed for rheumatoid arthritis, showed potential benefits for patients with nail dystrophy, particularly those whose condition was resistant to conventional treatments. This finding suggested a new therapeutic indication for tofacitinib in treating nail diseases associated with autoimmune conditions like psoriasis and psoriatic arthritis.

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research Reversal of Alopecia Universalis by Tofacitinib: A Case Report

14 citations , November 2016 in “Annals of Internal Medicine”

Tofacitinib, an arthritis drug, helped hair growth in alopecia universalis but long-term safety needs more research.

research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

238 citations , November 2016 in “Journal of The American Academy of Dermatology”

In this study, tofacitinib was reported to improve scalp hair regrowth in patients with severe alopecia areata, alopecia totalis, and alopecia universalis, showing a higher response in alopecia areata.

research Remarkable Improvement of Nail Changes in Alopecia Areata Universalis with 10 Months of Treatment with Tofacitinib: A Case Report

26 citations , October 2016 in “Case Reports in Dermatology”

In this study, tofacitinib treatment in a male patient with alopecia areata led to significant hair regrowth and improvement in nail dystrophy symptoms, restoring finger function within 10 months.

research Familial Aggregation of Alopecia Areata

295 citations , May 2016 in “Journal of the American Academy of Dermatology”

This review examines the immunological aspects of alopecia areata, focusing on genetic, neuroimmunological, and immune privilege factors, but does not report new clinical findings.

research Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated with Alopecia Universalis

41 citations , December 2015 in “JAMA Dermatology”

Tofacitinib citrate improved nail dystrophy and pain in patients with alopecia universalis without causing side effects.

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

185 citations , June 2014 in “Journal of Investigative Dermatology”

This case report describes complete hair regrowth in a patient with alopecia universalis and improved psoriasis after treatment with the oral Janus kinase inhibitor, tofacitinib.