Recovery of Nail Dystrophy: Potential New Therapeutic Indication of Tofacitinib

February 2017 in “ Clinical rheumatology ”

Jose A. Jaller, Juan José Jaller, Antonio M. Jaller, Juan J. Jaller-Char, Sineida Berbert Ferreira, Rachel Berbert Ferreira, Morton Scheinberg

tofacitinib nail dystrophy rheumatoid arthritis psoriasis psoriatic arthritis autoimmune conditions Xeljanz

TLDR Tofacitinib may help treat nail dystrophy, especially when other treatments fail.

The document reported that tofacitinib, a therapy initially developed for rheumatoid arthritis, showed potential benefits for patients with nail dystrophy, particularly those whose condition was resistant to conventional treatments. This finding suggested a new therapeutic indication for tofacitinib in treating nail diseases associated with autoimmune conditions like psoriasis and psoriatic arthritis.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Reversal of Alopecia Universalis by Tofacitinib: A Case Report

14 citations, November 2016 in “Annals of Internal Medicine”

Tofacitinib, an arthritis drug, helped hair growth in alopecia universalis but long-term safety needs more research.

research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

238 citations, November 2016 in “Journal of The American Academy of Dermatology”

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

research Remarkable Improvement of Nail Changes in Alopecia Areata Universalis with 10 Months of Treatment with Tofacitinib: A Case Report

26 citations, October 2016 in “Case Reports in Dermatology”

A man with severe hair loss saw hair and nail improvement after 10 months on tofacitinib without side effects.

research Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated with Alopecia Universalis

41 citations, December 2015 in “JAMA Dermatology”

Tofacitinib citrate improved nail dystrophy and pain in patients with alopecia universalis without causing side effects.

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

185 citations, June 2014 in “Journal of Investigative Dermatology”

A man with severe hair loss and skin disease regrew his hair with no side effects after taking tofacitinib.

research Familial Aggregation of Alopecia Areata

295 citations, January 2006 in “Journal of the American Academy of Dermatology”

Alopecia areata, a common autoimmune hair loss condition, often runs in families.

Similar Research

5 / 688 results

Recovery of Nail Dystrophy: Potential New Therapeutic Indication of Tofacitinib

Research cited in this study

research Reversal of Alopecia Universalis by Tofacitinib: A Case Report

research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

research Remarkable Improvement of Nail Changes in Alopecia Areata Universalis with 10 Months of Treatment with Tofacitinib: A Case Report

research Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated with Alopecia Universalis

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

research Familial Aggregation of Alopecia Areata

Related Community Posts Join

community Finasteride and Oral Minoxidil in Turkey - what I’ve found out

community 22F. Should I even bother getting a biopsy? Is there any point?

community No hair, don't care! [24/F] :)

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

community What else is good. Besides the big 3.

community The shedding caused by Minoxidil is one of the worst things. 2 months apart each picture

Similar Research

research JAK Inhibitors for the Treatment of Alopecia Areata

research Janus Kinase Inhibitors in Dermatology: A Systematic Review

research Nail Involvement in Patients with Moderate-to-Severe Alopecia Areata Treated with Oral Tofacitinib

research A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata

research Janus Kinase (JAK) Inhibitors for the Treatment of Skin and Hair Disorders: A Review of Literature