Trachyonychia Secondary to Pediatric Alopecia Areata Responding to Oral Tofacitinib Therapy: A Case Report and Review of Literature

    January 2025 in “ International Journal of Dermatology ”
    Parul Bansal, Akash Agarwal, Maitreyee Panda
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    TLDR Tofacitinib improved hair and nail conditions in a teen with alopecia areata.
    A 14-year-old male with alopecia areata subtotalis and trachyonychia showed significant improvement after treatment with oral tofacitinib, a JAK inhibitor. Previous treatments with betamethasone and cyclosporine were ineffective for his nail condition. Tofacitinib, combined with topical minoxidil, led to complete hair regrowth and improved nail texture within 6 months, with the disease remaining in remission 6 months post-treatment. This case highlights tofacitinib's potential in treating resistant nail changes in alopecia areata, though further research is needed to confirm these findings.
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