Effectiveness of Oral Tofacitinib Treatment on Patients With Moderate-to-Severe Alopecia Areata in Iran

    November 2023 in “ Journal of Cosmetic Dermatology ”
    Ali Asilian, Parisa Mohammadian, Zabihollah Shahmoradi
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    TLDR Tofacitinib is effective and has minor, reversible side effects for treating severe hair loss in Iran.
    The study involved 47 patients with moderate-to-severe alopecia areata who were treated with oral tofacitinib, a Janus kinase inhibitor, for at least 6 months. After 18 months, hair loss decreased by 6.45 times and body hair loss decreased four times compared to the start of treatment. Only one patient experienced sensory-peripheral neuropathy, which recovered after treatment cessation. No other complications were observed. The study also found that alopecia areata patients had higher hair loss on the head, body, and nail involvement, especially those with other autoimmune diseases like vitiligo and hypothyroidism. The average maintenance dose was 7 mg daily, reducing the risk of side effects. The study concluded that tofacitinib is recommended for treating alopecia areata in Iran due to its effectiveness and minor, reversible side effects.
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      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  865 upvotes 9 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 10 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 4 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community Topical solution recommendation

      in Treatment  1 upvotes 3 weeks ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Topical solution recommendation

      in Product  1 upvotes 3 weeks ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

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