Janus Kinase Inhibitors: An Innovative Treatment for Alopecia Areata

    June 2019 in “ Journal of dermatology
    Hyun Sun Park, Duk Jun Yu, Oh Sang Kwon
    TLDR New medicines that block a specific pathway are showing promise for treating severe hair loss but need more testing for safety and effectiveness.
    The document discussed the potential of Janus kinase (JAK) inhibitors as an innovative treatment for alopecia areata (AA), a common disease with no satisfactory treatment. Research indicated that autoreactive cytotoxic T cells and the JAK pathway play crucial roles in AA's pathogenesis. Several single-arm clinical trials and retrospective studies showed that oral JAK inhibitors were effective and tolerable for moderate to severe AA. However, the document emphasized the need for further placebo-controlled clinical trials to confirm the efficacy and long-term safety of JAK inhibitors.
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