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Glossary Drug Targets

specific molecules drugs interact with to produce therapeutic effects

Drug targets, also known as pharmacological targets or therapeutic targets, are specific molecules in the body, often proteins, that drugs interact with to produce a therapeutic effect. These targets can include enzymes, receptors, ion channels, or other proteins involved in disease processes. By binding to these targets, drugs can modify their activity, leading to changes in cellular function and ultimately improving health outcomes.

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community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

110 upvotes 2 years ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

community Is there any new drug that looks promising ?

26 upvotes 2 years ago

The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

community Drug-free hair transplant while waiting for future treatments to become available to public: stupid or good plan?

in Transplants 1 month ago

A user plans a drug-free hair transplant while waiting for future treatments like stem cell therapies, which are projected to be available between 2028 and 2030. Many users express skepticism about the availability of new treatments, suggesting that relying on them is risky and that finasteride remains the most effective option.

community Who is the ideal target for PP405? Will it render hair trasplants obsolete?

2 upvotes 5 months ago

PP405 is being discussed as a potential treatment for hair loss, with uncertainty about its effectiveness compared to existing treatments like finasteride, dutasteride, and minoxidil. There is cautious optimism, but its impact on hair transplants remains unclear.

community Targeted Follicular Finasteride Delivery: A Low-Systemic Strategy

15 upvotes 5 months ago

A peptide-based delivery system for finasteride shows promise in reducing systemic side effects while maintaining hair growth effectiveness. Combining this with other treatments like minoxidil and RU58841 could enhance results with lower systemic absorption.

community Target Area Hair Count (TAHC) increase comparasion of all future treatments in clinical trial phases

in Research/Science 35 upvotes 2 years ago

Finasteride, Minoxidil, Bioneer CosmeRNA, Technoderma, Kintor, Hope, Breezula, and Follicum treatments showed increases in hair count, with Technoderma showing the highest increase at 24.3 hairs/cm². Amplifica has not yet published results.

community A concern regarding the upcoming androgen degrader drug GT20029

11 upvotes 1 year ago

GT20029 is a topical treatment that degrades androgen receptors to prevent hair thinning and loss, potentially offering fewer side effects than systemic treatments like finasteride. Concerns include its impact on hair texture and potential systemic effects, with market availability speculated in 3 to 5 years.

community Finasteride really is a miracle drug

in Finasteride/Dutasteride 181 upvotes 8 months ago

Finasteride and minoxidil help maintain hair and slightly improve hairlines but are less effective at regrowing hair in bald areas, often needing a hair transplant for full restoration. Many users report no side effects and wish they had started treatment earlier.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Wouldn’t it be funny if there already was a drug that existed which reactivated sleeping follicles? It would be our own version of Ozempic

202 upvotes 1 year ago

PP405 shows promise for reactivating hair follicles, with potential maintenance using 5AR inhibitors. Current treatments like Minoxidil and finasteride are effective but have limitations, and there is hope for more effective solutions in the future.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Anagen (@anagenxyz) claiming they've cracked scalp-only DHT blocking - thoughts?

15 upvotes 1 week ago

A company is developing a topical dutasteride that targets hair follicles without significantly affecting systemic DHT levels, with trials underway to measure its effectiveness. Users discuss the potential benefits and skepticism around the formulation compared to existing treatments.

community How does castor oil improve hair growth?

7 upvotes 6 years ago

Castor oil may help hair growth by targeting specific receptors and reducing certain scalp levels, with some users reporting thicker hair. Peppermint oil is suggested as an alternative to minoxidil, while opinions on the effectiveness of plant-based treatments for hair loss vary.

community Pelage, PP405, is creating a database for potential new trial volunteers

148 upvotes 11 months ago

PP405 is a new hair loss treatment targeting dormant hair follicles, with ongoing trials. Some users consider stopping finasteride and minoxidil to join trials, while others doubt its effectiveness.

community Topical fin - why are people still using alcohol carriers when liposomal is proven to be better?

7 upvotes 1 year ago

Liposomal carriers for topical finasteride offer better targeting, reduced side effects, and less irritation compared to alcohol-based solutions, but availability and cost may limit their use. Minoxidil can dissolve in liposomal carriers, enhancing delivery and stability.

community A Short Recap on PP405 and AAD 2026

in Update 5 months ago

PP405 is a promising experimental topical treatment for alopecia that reactivates dormant hair follicles by targeting cellular energy, with large-scale trials planned for 2026. While it shows potential, it cannot regenerate permanently destroyed follicles, making hair transplants the only guaranteed solution for advanced baldness currently.

community GT20029: How It Works for Hair Loss - Hair Loss “Cure”

38 upvotes 7 months ago

GT20029 is a potential treatment for androgenetic alopecia, addressing the root cause by targeting androgen receptors, unlike Minoxidil or Finasteride. It is seen as a preventative measure rather than a regrowth agent, with hopes for market release soon.

community Finasteride and Dutasteride results compilation thread

in Finasteride/Dutasteride 83 upvotes 1 year ago

Combining finasteride and dutasteride may enhance hair regrowth by targeting different enzymes, with positive results reported. Minoxidil, both oral and topical, is also used to improve effectiveness.

community deeper understanding of microneedling

16 upvotes 3 years ago

Microneedling can enhance hair growth by increasing drug absorption and activating stem cells, with different needle depths serving distinct purposes. Users report success with microneedling, often in combination with treatments like minoxidil and finasteride, and emphasize waiting periods for topical application to avoid side effects.

community Breezula Phase 3 Results enough for maintenance?

13 upvotes 4 months ago

Breezula shows promise in stabilizing hair loss and potentially promoting regrowth at the one-year mark, offering hope for those who can't tolerate 5AR inhibitors. Its local targeting of androgen receptors could be a significant advancement if it avoids systemic side effects.

community REVOLUTION in AUGUST: New possibilities according to Dr. Muñoz (pinacidil, cromakalim, diazoxide and nicorandil)

13 upvotes 1 year ago

Dr. Muñoz's discovery suggests that targeting potassium channels in fibroblasts could reactivate hair growth, offering new treatment possibilities for alopecia. Potential strategies include using minoxidil, diazoxide, and other potassium channel openers, as well as bioelectric devices and direct growth factor applications.

community New angles to attack beyond DHT

4 upvotes 2 years ago

Exploring hair loss treatments beyond DHT, including Minoxidil, pyruvate, Gt20029 targeting androgen receptors, and vasodilators. Other options like Kx826, adenosine signaling, growth factor topicals, and microneedling are also discussed.

community End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁

276 upvotes 6 months ago

GT20029 is a new hair loss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.

community We should actually be hopeful for these recent new developments

112 upvotes 1 year ago

AI advancements, like AlphaFold, are speeding up drug discovery for hair loss, promising more effective treatments. Current options like minoxidil and finasteride have limitations, but new developments could improve solutions in 5-10 years.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Why hasn’t anyone made a "DHT sponge" biologic yet???

in Research/Science 45 upvotes 10 months ago

The conversation discusses the potential for developing a biologic "DHT sponge" to neutralize DHT in the bloodstream as a treatment for hair loss, suggesting it could be more targeted and have fewer side effects than current treatments like finasteride and dutasteride. Concerns include the complexity, cost, and potential side effects of such a treatment, as well as skepticism about its feasibility and market interest.

community Are there ever going to be any oral DHT blocking treatments in the future?

5 upvotes 2 years ago

The discussion revolves around the need for future oral DHT blockers for hair loss treatment that don't have the side effects of current options like Finasteride and Dutasteride. One user suggests that the future of hair loss treatment will likely be topical anti-androgens, as they can target hair follicles without affecting the entire system.

community Why you can still look forward to PP405 and JXL-069

22 upvotes 1 month ago

PP405 and JXL-069 are the same compound, but users experienced no results due to flawed application methods. The topical gel formulation of PP405 is designed to target hair follicle stem cells effectively, unlike liquid solutions that fail to penetrate deeply.

community Most promising cures for baldness as of May 2026

70 upvotes 4 months ago

PP405 is the most promising future treatment for hair loss, aiming to reactivate dormant hair follicles. Clascoterone 5% is the most promising near-term drug, while current strategies include using finasteride or dutasteride to stabilize hair loss and minoxidil to stimulate growth.

community will pp405 be able to bring my lost temple area back to the game?

10 upvotes 5 months ago

A user is concerned about hair loss in the temple area despite using Minoxidil and finasteride for 10 months and is curious if PP405 can help. Responses indicate uncertainty about PP405's effectiveness, with some optimism about future treatments and AI speeding up drug discovery, but emphasize waiting for clinical trial results.