Has anyone ordered JXL-069 (grey market PP405)?
    Research/Science 3/17/2025

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    In this question or advice post, the primary subjects mentioned are
    ๐Ÿ’ง JXL-069 (PP405) (topical) 0.05% daily
    the tone is ๐Ÿ˜ neutral.

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    People are discussing JXL-069 (PP405) for hair loss, with some experimenting with a 0.05% topical gel. Concerns about safety and efficacy persist due to limited testing and lack of official approval.
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      PP405 Identity Research

      community PP405 Identity Research

      in Research  292 upvotes 1 month ago
      PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

      community Jxl069 (pp405 api) week 8 update

      in Progress Pictures  183 upvotes 1 month ago
      The user shared minimal results from using JXL-069 for hair loss, noting a slight lengthening of vellus hairs and plans to switch to a prodrug variant due to limited effectiveness. They also mentioned using finasteride and minoxidil, which have plateaued in results.

      community I want to attempt to use the MPC inhibitor JXL-069

      in Research/Science  14 upvotes 6 months ago
      The conversation discusses skepticism about group buys for hair loss treatments, highlighting issues with unverified chemicals and the risks involved. It suggests stabilizing with dutasteride and minoxidil, and considering a hair transplant instead of experimenting with untested products.

      community When could we expect pp405 to hit the market?

      in Research/Science  30 upvotes 5 months ago
      PP405 is expected to finish Phase 2 trials in late 2025, with potential market availability around 2028-2029 if all goes well. Current treatments like finasteride and minoxidil are still popular, while new options like KX-826 and Breezula are anticipated soon.

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