Psoriasis Is Characterized by Deficient Negative Immune Regulation Compared to Transient Delayed-Type Hypersensitivity Reactions
June 2015
in “
F1000Research
”
psoriasis negative immune regulation IL-10 CTLA4 PD1 PDL1 PDL2 IDO1 delayed-type hypersensitivity DTH diphenylcyclopropenone DPCP chronic inflammation interleukin-10 cytotoxic T-lymphocyte-associated protein 4 programmed cell death protein 1 programmed death-ligand 1 programmed death-ligand 2 indoleamine 2,3-dioxygenase 1
TLDR Psoriasis may be chronic because it lacks certain immune system controls that prevent overreaction.
The study concluded that psoriasis was characterized by significantly lower expression of negative immune regulatory genes, such as IL-10, CTLA4, PD1, PDL1, PDL2, and IDO1, compared to delayed-type hypersensitivity (DTH) reactions induced by diphencyprone (DPCP). This deficiency in negative immune regulation might contribute to the chronic inflammation seen in psoriasis. The findings suggested that enhancing these negative regulatory pathways could be a potential therapeutic strategy for treating psoriasis. The study involved 11 volunteers for DPCP reactions and a meta-analysis of 193 psoriatic skin samples.
