Psoriasis Is Characterized by Deficient Negative Immune Regulation Compared to Transient Delayed-Type Hypersensitivity Reactions

    June 2015 in “ F1000Research ”
    Nicholas Gulati, Mayte Suárez‐Fariñas, Joel Correa da Rosa, James G. Krueger
    TLDR Psoriasis may be chronic because it lacks certain immune system controls that prevent overreaction.
    The study concluded that psoriasis was characterized by significantly lower expression of negative immune regulatory genes, such as IL-10, CTLA4, PD1, PDL1, PDL2, and IDO1, compared to delayed-type hypersensitivity (DTH) reactions induced by diphencyprone (DPCP). This deficiency in negative immune regulation might contribute to the chronic inflammation seen in psoriasis. The findings suggested that enhancing these negative regulatory pathways could be a potential therapeutic strategy for treating psoriasis. The study involved 11 volunteers for DPCP reactions and a meta-analysis of 193 psoriatic skin samples.
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