Induction of Synapse Associated Protein 102 Expression in Cyclosporin A-Stimulated Hair Growth

    February 2008 in “ Experimental Dermatology ”
    Chang Deok Kim, Minho Lee, Kyung-Ah Sohn, Jin Man Kim, Sheng Jin Li, Moon‐Jeong Rang, Seok-Seon Roh, Young-Seon Oh, Tae‐Jin Yoon, Myung Im, Young‐Joon Seo, Jeung‐Hoon Lee, Jang-Kyu Park
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    TLDR Cyclosporin A promotes hair growth in mice and increases a protein linked to hair growth, but it may not work the same way in humans.
    In the 2008 study, researchers found that Cyclosporin A (CsA) applied topically to mice induced a transition from the resting phase to the growth phase of hair follicles, suggesting a positive effect on hair growth. However, CsA did not stimulate growth in cultured human hair follicle tissues, indicating that its effects might not directly translate to human hair growth. The study also discovered an increase in synapse associated protein 102 (SAP102) expression in the skin of CsA-treated mice, which was also present during the natural growth phase of hair, suggesting that SAP102 is associated with hair growth. SAP102 was not expressed in cultured human hair cells, and its expression was localized to the perifollicular region of mouse hair, implying that its role in hair growth is not direct and requires further investigation.
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