Comparison of Two Encapsulated Curcumin Systems in Different Formulations for In Vitro Skin Penetration

    January 2012 in “ Skin Research and Technology ”
    Natthakitta Suwannateep, Supason Wanichwecharungruang, Joachim W. Fluhr, Alexa Patzelt, Jürgen Lademann, Martina C. Meinke
    TLDR The w/o lotion with blended cellulose improved curcumin skin penetration best.
    The study investigated the encapsulation of curcumin into two different polymers, ethyl cellulose and methyl cellulose blended ethyl cellulose, achieving a loading capacity of approximately 46-48%. The in vitro skin penetration of these encapsulated curcumin systems was tested on porcine ear skin using laser scanning microscopy. Results indicated that o/w and w/o lotions enhanced the follicular penetration of curcumin particles more effectively than water suspensions, with w/o lotions being superior to o/w lotions. The use of ethyl cellulose blended with methyl cellulose further improved curcumin penetration across all formulations. The study concluded that these high-loaded encapsulated curcumin systems could effectively transport curcumin into the skin.
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