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Glossary Lipophilic Drugs

dissolve in fats and easily cross cell membranes

Lipophilic drugs, also known as fat-soluble drugs, are medications that dissolve in fats, oils, and lipids rather than water. This property allows them to easily cross cell membranes, which are composed of lipid bilayers, facilitating their absorption and distribution within the body. These drugs often have longer half-lives and can accumulate in fatty tissues, potentially leading to prolonged effects or toxicity.

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Research

5 / 1000+ results

research Mechanism of transdermal permeation promotion of lipophilic drugs by ethosomes

105 citations , April 2017 in “International Journal of Nanomedicine”

In this study, ethosomes were found to improve the skin penetration of a model lipophilic drug more effectively than liposomes or hydroethanolic solutions, suggesting a unique mechanism involving the breakdown of vesicles in the skin.

research Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream

132 citations , April 2007 in “European journal of pharmaceutics and biopharmaceutics”

This study found that an oil-in-water microemulsion of curcumin penetrated deeper into the human stratum corneum and hair follicles compared to an amphiphilic cream.

research Liposomal systems as drug delivery vehicles for dermal and transdermal applications

151 citations , July 2011 in “Archives of Dermatological Research”

This review discusses various strategies to enhance drug delivery through the skin barrier, highlighting liposomes as promising carriers for increased dermal concentrations in topical therapies, but reports no new research results.

Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro

research Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro

82 citations , January 2002 in “Journal of drug targeting”

This study found that drug delivery through human scalp skin may be more effective for lipophilic and hydrophilic drugs compared to abdominal skin, highlighting the potential of intrafollicular delivery methods.

research Liposomes with an Ethanol Fraction as an Application for Drug Delivery

24 citations , November 2018 in “International Journal of Molecular Sciences”

This review discusses ethosomes as lipid carriers that enhance drug penetration into deep skin layers and underscores the need for advanced research on their pharmaceutical applications, but it reports no clinical outcomes.

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community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

23 upvotes 1 year ago

Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

community Soundwaves & Electricity Grows Hair? | Peptide Delivery Model.

2 upvotes 2 years ago

Iontophoresis and sonophoresis can enhance drug delivery into the scalp. Combining these methods may improve the effectiveness of topical treatments like dutasteride and certain peptides.

community Reminder: you can get dutasteride for $6.33 / month in the United States

in Finasteride/Dutasteride 67 upvotes 1 year ago

Dutasteride can be obtained for $6.33 per month in the US through Cost Plus Drugs, with prescriptions easily switched from finasteride by contacting a doctor. Users discuss various methods to obtain affordable dutasteride, including using online pharmacies and considering generic options, while cautioning against buying from unreliable sources like eBay.

community Real world data from Europe shows that DUT is significantly safer than FIN in long term use

531 upvotes 1 year ago

Dutasteride is safer than finasteride for long-term use, with fewer sexual side effects. Users experience better hair regrowth and fewer side effects with dutasteride.

community Topical Dutasteride & Microneedling Works

4 upvotes 2 years ago

Topical dutasteride, especially at higher concentrations, can be effective for hair loss when combined with microneedling to enhance absorption. Users discuss the side effects of finasteride and dutasteride, with some preferring topical treatments to avoid systemic side effects.

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