TLDR A new method accurately measures clobetasol propionate in hair and skin.
The study developed a simple HPLC-UV method for quantifying clobetasol propionate (CLO) in hair follicles and different skin layers, addressing the need for precise drug delivery in alopecia treatment. Using a RP-C18 column and a specific mobile phase, the method achieved CLO elution at 10.1 minutes with high resolution from skin matrix interferences. Validation followed International Conference on Harmonization guidelines, ensuring selectivity, linearity (0.5–15.0 μg/mL), robustness, precision, accuracy, and detection limits (0.02 and 0.07 μg/mL). The method was successfully applied in in vitro skin permeation and hair follicle deposition experiments, proving its effectiveness for CLO quantification.
The user is considering switching to oral dutasteride, topical minoxidil, retinoic acid, and clobetasol for hair loss treatment, after limited regrowth with finasteride and other topicals. They are seeking a source for clobetasol, as they believe it may help with their condition.
A new topical medication, Clascoterone, shows promise for hair loss, improving hair count significantly. Trials for Breezula are ending, but sign-ups for PP405 trials are available for 2026.
Hair loss treatment with latanoprost, minoxidil, and biotin showed progress. Latanoprost, a glaucoma drug, stimulates anagen phase and increases conversion of vellus hair to terminal hair.
The conversation discusses using scalp antiandrogens like RU58841, pyrilutamide, or fluridil on the face to reduce sebum production, noting that clascoterone (winlevi) is an approved facial antiandrogen with underwhelming reviews.
A user was prescribed a topical treatment for hair loss including Latanoprost, Minoxidil, Dutasteride, Hydrocortisone, and Progesterone, after using an oral Minoxidil and Finasteride combo without significant results. Concerns were raised about the long-term use of hydrocortisone, with suggestions to consult a doctor regularly.
The user visited a trichologist due to ineffective topical finasteride treatment for hair loss. The trichologist recommended a new regimen including a two-month course of locoidon (cortisone 0.1%), followed by a solution containing minoxidil, hydrocortisone butirrate, estrone, progesterone, tocopherol acetate, trichosol, and transcutol.
7 citations
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February 2018 in “International Journal of Pharmaceutics”
Researchers developed a method to measure drugs in hairfollicles and found that both water-loving and fat-loving drugs can be detected after being applied to the skin.
