Determination of Steroid Hormones in Human Hair as a Retrospective Biomarker with HPLC-MS/MS

    September 2012 in “ European journal of psychotraumatology ”
    Wei Gao, Tobias Stalder, Susann Steudte, Clemens Kirschbaum, Paul Foley, Manfred Rauh, Huihua Deng
    TLDR A new method accurately measures long-term hormone levels in hair.
    The study developed a new LC-MS/MS-based method for identifying concentrations of seven steroid hormones in human hair, offering improved specificity, sensitivity, and reproducibility over traditional immunochemical assays. This method allowed for the simultaneous measurement of cortisol, cortisone, testosterone, progesterone, corticosterone, DHEA, and androstendione, with detection limits ranging from 0.1 to 9.0 pg/mg and linear ranges up to 1000 pg/mg. The findings suggested that this approach could enhance the accuracy of psychoneuroendocrinological research by providing a reliable retrospective assessment of long-term hormone secretion.
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