Decreased IL-10 Producing Regulatory B Cells in Patients With Alopecia Areata
TLDR People with alopecia areata have fewer IL-10 producing immune cells, which might contribute to the condition.
The study investigated the role of IL-10 producing regulatory B cells (Bregs) in patients with alopecia areata (AA) by analyzing B cell subsets in the peripheral blood of 17 AA patients and 8 healthy volunteers. The results showed a significant decrease in the frequency of total and IL-10 producing CD19+CD24hiCD38hi B cells in AA patients compared to healthy volunteers (P<0.001). This deficiency in IL-10 producing Bregs may contribute to the autoimmune response in AA by disrupting hair follicle immune privilege and promoting Th1 and Th17 cytokine production. The findings suggest that targeting IL-10 producing Bregs could be a potential therapeutic approach for AA.
