Decreased IL-10 Producing Regulatory B Cells in Patients With Alopecia Areata

    April 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    J. Park, K. Nam, G. Lee, S. Yun, J. Choi
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    TLDR People with alopecia areata have fewer IL-10 producing immune cells, which might contribute to the condition.
    The study investigated the role of IL-10 producing regulatory B cells (Bregs) in patients with alopecia areata (AA) by analyzing B cell subsets in the peripheral blood of 17 AA patients and 8 healthy volunteers. The results showed a significant decrease in the frequency of total and IL-10 producing CD19+CD24hiCD38hi B cells in AA patients compared to healthy volunteers (P<0.001). This deficiency in IL-10 producing Bregs may contribute to the autoimmune response in AA by disrupting hair follicle immune privilege and promoting Th1 and Th17 cytokine production. The findings suggest that targeting IL-10 producing Bregs could be a potential therapeutic approach for AA.
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