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GlossaryT helper 1 cells (Th1 cells)

specialized immune cells that produce cytokines to fight infections

T helper 1 cells, often abbreviated as Th1 cells, are a subset of T cells that play a crucial role in the immune system by producing cytokines like interferon-gamma (IFN-γ). These cytokines help activate macrophages and are essential for defending against intracellular pathogens such as viruses and certain bacteria. Th1 cells are also involved in the pathogenesis of autoimmune diseases by promoting inflammation.

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The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients

research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients

18 citations , January 2017 in “Annals of dermatology/Annals of Dermatology”

Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.

research Spatial transcriptome reveals disturbance of peri-infundibular immune infiltration in androgenetic alopecia

June 2023 in “Research Square (Research Square)”

Hair loss in male pattern baldness is linked to changes in immune cell behavior around hair follicles.

research Editors' Picks

February 2012 in “Journal of Investigative Dermatology”

Small molecule DMF improves psoriasis and multiple sclerosis, adult skin cells can be made to grow new hair, certain skin cells initiate hair growth, IL-17C controls gut health and can cause skin inflammation, and skin cells produce IL-17 that can lead to psoriasis.

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February 2011 in “Journal of Clinical Investigation”

Genetically repaired stem cells may treat certain genetic diseases, Th17 cells are key in fighting systemic fungal infections, hair loss in AGA is due to progenitor cell loss, and α-synuclein transfer might contribute to Parkinson's disease progression.

research Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model

69 citations , March 2008 in “The American journal of pathology”

Controlled delivery of specific RNA and IL-4 restored hair growth in mice with autoimmune alopecia.

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community When someone posts a scalp tension theory

in Satire 268 upvotes 3 years ago

Hair loss theories discussed include poor blood flow, scalp tension, inflammation, and DHT. Treatments mentioned are massaging scalp, minoxidil, finasteride, and RU58841.