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GlossaryT helper 1 cells (Th1 cells)

specialized immune cells that produce cytokines to fight infections

T helper 1 cells, often abbreviated as Th1 cells, are a subset of T cells that play a crucial role in the immune system by producing cytokines like interferon-gamma (IFN-γ). These cytokines help activate macrophages and are essential for defending against intracellular pathogens such as viruses and certain bacteria. Th1 cells are also involved in the pathogenesis of autoimmune diseases by promoting inflammation.

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Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

research Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

278 citations, March 2013 in “Gut”

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

Alopecia Universalis Following Two Sequential Traffic Accidents: Possible Association with Increased Th1 and Th17 Cells and Decreased Th2 Cells

research Alopecia Universalis Following Two Sequential Traffic Accidents: Possible Association with Increased Th1 and Th17 Cells and Decreased Th2 Cells

4 citations, January 2011 in “Journal of UOEH”

Autoimmune hair loss may be linked to increased Th1 and Th17 cells and decreased Th2 cells.

research Detection of Subtypes of T Helper Cells and Their Cytokines in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Their Clinical Significances

January 2014 in “Journal of Jilin University”

Higher levels of certain immune cells and proteins are linked to more severe lupus symptoms.

The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

18 citations, January 2017 in “Annals of dermatology/Annals of Dermatology”

Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.

research Spatial Transcriptome Reveals Disturbance of Peri-Infundibular Immune Infiltration in Androgenetic Alopecia

June 2023 in “Research Square (Research Square)”

Hair loss in male pattern baldness is linked to changes in immune cell behavior around hair follicles.

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community When someone posts a scalp tension theory

in Satire 264 upvotes 3 years ago

Hair loss theories discussed include poor blood flow, scalp tension, inflammation, and DHT. Treatments mentioned are massaging scalp, minoxidil, finasteride, and RU58841.