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research 1432 IL-9/IL-9R signaling as a novel regulator of human hair follicle growth and immune privilege

April 2023 in “Journal of Investigative Dermatology”

In ex vivo organ culture of human scalp hair follicles, this study found that IL-9 signaling inhibits hair growth, reduces progenitor cell generation, and disrupts immune privilege.

IL-9 Mediated Human Primary Keratinocytes Invasion Is Dependent on MLC Controlled Contractility and Independent of MMP Activity

research 879 IL-9 mediated human primary keratinocytes invasion is dependent on MLC controlled contractility and independent of MMP activity

April 2018 in “Journal of Investigative Dermatology”

This study found that IL-9 influences the behavior of human primary keratinocytes by promoting motility while reducing invasion potential through a novel mechanism independent of matrix-metalloproteinases.

Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Nonscarring Alopecia

research Proprietary Herbal Extract Downregulates the Gene Expression of Il-1 and #945; in HaCaT Cells: Possible Implications Against Nonscarring Alopecia

7 citations , January 2018 in “Medicinski arhiv”

In this study, a herbal extract mixture significantly reduced IL-1α gene expression in HaCaT cells, suggesting it may aid in the treatment of nonscarring alopecia.

research Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing

176 citations , August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.

research Identification of clustered cells in human hair follicle responsible for MMP‐9 gelatinolytic activity: consequences for the regulation of hair growth

27 citations , June 2001 in “International Journal of Dermatology”

This study found that cytokine and EGF stimulation leads to increased MMP-9 production in hair follicles, a process involved in hair follicle involution associated with alopecia.

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Learn

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learn Hair Transplant

What is the success rate of hair transplants? Hair transplants generally have a high success rate, but results can vary.
Is a hair transplant permanent? Transplanted hair is generally permanent but requires ongoing care to maintain results.
How much does a hair transplant cost? Hair transplant costs typically range from $1,000 to $25,000 depending on various factors.
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learn Scalp Micropigmentation

How long does Scalp Micropigmentation last, and does it need touch-ups over time? Scalp micropigmentation lasts 2 to 8 years and requires touch-ups every 1 to 5 years.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Clinics

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Community Join

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community Il PP405 è molto promettente ma non è l'unico in grado di liberarci dalla iattura

3 upvotes 1 year ago

PP405 shows promise in hair loss treatment, but stem cell therapy using adipose-derived stem cells and ATP also successfully reversed androgenetic alopecia in mice. Stem cell therapy is costly, and some doubt the effectiveness of PP405 based on press releases.

community Progressi in 9 mesi, da luglio 2025 a marzo 2026

in Progress Pictures 153 upvotes 5 months ago

The user shared their 9-month hair regrowth progress using topical Minoxidil 5%, finasteride 0.05%, retinoic acid 0.01%, dermastamping, ketoconazole shampoo, and supplements like biotin. They experienced some hair density improvement but minimal change in the hairline, with initial side effects from finasteride that resolved after dosage adjustment.

community 9-Month Routine Update. Advice?

3 upvotes 5 months ago

The user has been using 1mg Finasteride and 5% topical Minoxidil for 9 months with little improvement and has recently added microneedling, showing slight progress. The new protocol includes switching to 5mg oral Minoxidil, continuing microneedling, and adding Anagenil Complex, while seeking advice on whether to stop topical Minoxidil and the effectiveness of Anagenil Complex.

community 9 months on Finasteride and still no progress and feeling hopeless

38 upvotes 11 months ago

The user has been using finasteride, minoxidil, microneedling, PRP, and ProCell therapy for hair loss but sees no progress after nine months. They are considering switching to dutasteride and possibly a hair transplant, with suggestions to add oral minoxidil.

community 4 months on fin 1mg daily only - can sum1 explain? 9/10 experience

4 upvotes 5 years ago

The user experienced significant hair density improvement and darker hair color after four months of taking 1mg finasteride daily, but also noticed temple recession. They started using oral castor oil and microneedling, hoping to prevent further temple recession.

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Experts

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